BioAssay by Target (List) for Gene (Select 10257) - PubChem BioAssay - NCBI

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Select item 18134551.

Inhibition of MRP4 (unknown origin)

Source:: ChEMBL

Protein Target:: Multidrug resistance-associated protein 4

Assay data:1 Active, 3 Tested

AID:: 1813455

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 15085882.

RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen

Source:: Victorian Centre for Functional Genomics, Peter MacCallum Cancer Centre

Assay data:790 Active, 18119 Tested

AID:: 1508588

Select item 14737413.

Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and GSH measured after 20 mins by membrane vesicle transport assay

Source:: ChEMBL

Protein Target:: Multidrug resistance-associated protein 4

Assay data:30 Active, 1 Activity ≤ 1 µM, 629 Tested

AID:: 1473741

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 14353254.

Inhibition of MRP4 in 7 mW/cm'2 irradiated human M14 cells assessed as reduction in ATPase activity at 5 uM measured after 20 mins in presence of doxorubicin by immunoblotting

Source:: ChEMBL

Protein Target:: Multidrug resistance-associated protein 4

Assay data:1 Active, 1 Tested

AID:: 1435325

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 14353215.

Inhibition of MRP4 in 7 mW/cm'2 irradiated human M14 cells assessed as nitration of tyrosine in MRP4 at 5 uM measured after 20 mins in presence of doxorubicin by immunoblotting

Source:: ChEMBL

Protein Target:: Multidrug resistance-associated protein 4

Assay data:1 Active, 1 Tested

AID:: 1435321

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 14352936.

Inhibition of MRP4 in 7 mW/cm'2 irradiated human M14 cells assessed as reduction in MRP4 ATPase activity at 5 uM measured after 20 mins by spectrophotometric method

Source:: ChEMBL

Protein Target:: Multidrug resistance-associated protein 4

Assay data:2 Active, 2 Tested

AID:: 1435293

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 14352897.

Inhibition of MRP4 in 7 mW/cm'2 irradiated human M14 cells assessed as nitration of tyrosine in MRP4 at 5 uM measured after 20 mins by immunoblotting

Source:: ChEMBL

Protein Target:: Multidrug resistance-associated protein 4

Assay data:2 Active, 2 Tested

AID:: 1435289

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 13468508.

Human ABCC4 (ABCC subfamily)

Source:: IUPHAR/BPS Guide to PHARMACOLOGY

Protein Target:: multidrug resistance-associated protein 4 isoform 2

Assay data:1 Active, 1 Tested

AID:: 1346850

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 12248309.

Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout

Source:: Iain Fraser

Assay data:2853 Active, 18113 Tested

AID:: 1224830

Summary Related BioAssays by Same Project

Select item 121990010.

Activity of recombinant human MRP4 expressed in adenovirus infected HEK293 cell plasma membrane vesicles assessed as transporter-mediated drug uptake after 2 mins by Michaelis-Menten plot analysis in presence of ATP

Source:: ChEMBL

Protein Target:: Multidrug resistance-associated protein 4

Assay data:2 Tested

AID:: 1219900

Summary PubMed Citation Related BioAssays by Target

Select item 121988811.

Activity of recombinant human ABCC4 expressed in baculovirus infected insect Sf21 cell plasma membrane vesicles assessed as transporter-mediated drug uptake per mg of protein by liquid scintillation counting analysis in presence of ATP

Source:: ChEMBL

Protein Target:: Multidrug resistance-associated protein 4

Assay data:1 Tested

AID:: 1219888

Summary PubMed Citation Related BioAssays by Target

Select item 121988512.

Activity of recombinant human ABCC4 expressed in baculovirus infected insect Sf21 cell plasma membrane vesicles assessed as transporter-mediated drug uptake by liquid scintillation counting analysis in presence of ATP

Source:: ChEMBL

Protein Target:: Multidrug resistance-associated protein 4

Assay data:1 Tested

AID:: 1219885

Summary PubMed Citation Related BioAssays by Target

Select item 121988213.

Activity of recombinant human ABCC4 expressed in baculovirus infected insect Sf21 cell plasma membrane vesicles assessed as transporter-mediated drug uptake at 10 uM by liquid scintillation counting analysis in presence of ATP

Source:: ChEMBL

Protein Target:: Multidrug resistance-associated protein 4

Assay data:1 Tested

AID:: 1219882

Summary PubMed Citation Related BioAssays by Target

Select item 121987514.

Inhibition of recombinant human ABCC4 expressed in baculovirus infected insect Sf21 cell plasma membrane vesicles assessed as inhibition of transporter-mediated [3H]-estradiol-17beta-glucuronide uptake by liquid scintillation counting analysis

Source:: ChEMBL

Protein Target:: Multidrug resistance-associated protein 4

Assay data:9 Active, 10 Tested

AID:: 1219875

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 121715815.

Inhibition of MRP4-mediated E2-17betaG transport in human MRP4 expressing HEK293 cells in presence of 0.6 to 5 uM E2-17betaG

Source:: ChEMBL

Protein Target:: Multidrug resistance-associated protein 4

Assay data:3 Active, 3 Tested

AID:: 1217158

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 121714816.

Inhibition of MRP4-mediated E2-17betaG transport in human MRP4 expressing HEK293 cells at 4 uM during 5 mins

Source:: ChEMBL

Protein Target:: Multidrug resistance-associated protein 4

Assay data:1 Tested

AID:: 1217148

Summary PubMed Citation Related BioAssays by Target

Select item 121714717.

Inhibition of MRP4-mediated E2-17betaG transport in human MRP4 expressing HEK293 cells at 1 to 3 uM during 5 mins

Source:: ChEMBL

Protein Target:: Multidrug resistance-associated protein 4

Assay data:4 Tested

AID:: 1217147

Summary PubMed Citation Related BioAssays by Target

Select item 121714618.

Inhibition of MRP4-mediated E2-17betaG transport in human MRP4 expressing HEK293 cells at 7 uM during 5 mins

Source:: ChEMBL

Protein Target:: Multidrug resistance-associated protein 4

Assay data:2 Active, 2 Tested

AID:: 1217146

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 121714519.

Inhibition of MRP4-mediated E2-17betaG transport in human MRP4 expressing HEK293 cells at 33 uM during 5 mins

Source:: ChEMBL

Protein Target:: Multidrug resistance-associated protein 4

Assay data:1 Active, 1 Tested

AID:: 1217145

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 121714420.

Inhibition of MRP4-mediated E2-17betaG transport in human MRP4 expressing HEK293 cells at 12 uM during 5 mins

Source:: ChEMBL

Protein Target:: Multidrug resistance-associated protein 4

Assay data:1 Active, 2 Tested

AID:: 1217144

Summary Compounds, Active PubMed Citation Related BioAssays by Target

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Target

Proteins (1)
BioAssays with protein sequences specified as targets
RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (23)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 µM (2)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (17)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (9)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (97)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (13)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (26)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (83)
BioAssays deposited by other experimentalists

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BioAssay by Target (List) for Gene (Select 10257) (110)
PubChem BioAssay
Assembly Links for BioProject (Select 78585) (1)
Assembly
Homo sapiens DnaJ heat shock protein family (Hsp40) member C3 (DNAJC3), RefSeqGe...
Homo sapiens DnaJ heat shock protein family (Hsp40) member C3 (DNAJC3), RefSeqGene on chromosome 13
gi|751130526|ref|NG_041830.1|

Nucleotide
BioAssay, by Gene target for Gene (Select 5611) (13)
PubChem BioAssay

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