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Metabolic stability in minipig hepatocytes assessed as intrinsic clearance measured per 10^6 cells
Assay data:1 Tested
SummaryPubMed Citation
Metabolic stability in minipig liver microsomes assessed as intrinsic clearance
Metabolic stability in mini-pig liver microsomes assessed as compound remaining after 1 hr
Inhibition of pig brain tubulin polymerization by spectrophotometeric analysis
Assay data:5 Active, 14 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of pig brain tubulin polymerization at 6 uM by spectrophotometer analysis
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of pig brain tubulin polymerization at 12.5 uM by spectrophotometer analysis relative to control
Inhibition of pig brain tubulin polymerization at 6 uM by spectrophotometer analysis relative to control
Inhibition of pig brain tubulin polymerization at 3 uM by spectrophotometer analysis relative to control
Apparent oral clearance in Gottingen minipig at 20 mg/kg measured upto 24 hrs by HPLC-MS method
Assay data:3 Tested
AUC (0 to t) in Gottingen minipig at 20 mg/kg, po measured upto 24 hrs by HPLC-MS method
Cmax in Gottingen minipig at 20 mg/kg, po measured upto 24 hrs by HPLC-MS method
Half life in Gottingen minipig at 20 mg/kg, po measured upto 24 hrs by HPLC-MS method
Clearance in Gottingen minipig at 5 mg/kg, iv measured upto 24 hrs by HPLC-MS method
AUC (0 to t) in Gottingen minipig at 5 mg/kg, iv measured upto 24 hrs by HPLC-MS method
Cmax in Gottingen minipig at 5 mg/kg, iv measured upto 24 hrs by HPLC-MS method
Half life in Gottingen minipig at 5 mg/kg, iv measured upto 24 hrs by HPLC-MS method
Protein binding in minipig plasma assessed as unbound fraction
Cmax in Yucatan minipig at 300 mg/kg, po using radiolabeled compound administered for 3 weeks
Cmax in Yucatan minipig at 125 mg/kg, po using radiolabeled compound administered for 3 weeks
Cmax in Yucatan minipig at 50 mg/kg, po using radiolabeled compound administered for 3 weeks
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