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Volume of distribution in papio anubis baboon thalamus assessed as increased in drug accumulation
Assay data:1 Tested
SummaryPubMed Citation
Volume of distribution in papio anubis baboon striatum assessed as increased in drug accumulation
Volume of distribution in Papio anubis brain administered intravenously measured upto 180 mins by PET analysis
Drug uptake in Papio anubis striatum relative to control
Drug metabolism in Papio anubis baboon plasma assessed as polar radio metabolite at 10 mins postinjection
In vivo binding affinity of Papio anubis baboon 5-HT2C assessed as inhibition constant measured after 1 to 21 mins postinjection
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
In vivo receptor occupancy at mGlu5 in baboon assessed as total plasma concentration required to show 50% effect up to 0.56 mg/kg, iv administered over 20 mins for 30 mins prior to [18F]-FPEB addition by microPET imaging analysis
Metabolic stability of the compound in baboon plasma at 20 kBq/ml at 37 degC by radio-HPLC analysis
Drug level in baboon plasma assessed as radioactivity treated with [18F]DPA714 measured after 30 to 120 mins by radio-HPLC analysis relative to total radioactivity
Drug uptake in brainstem of baboon neuroinflammation model assessed as drug distribution volume at 110 +/- 34 MBq, iv after 180 mins by PET imaging analysis
Drug uptake in frontal cortex of baboon neuroinflammation model assessed as drug distribution volume at 110 +/- 34 MBq, iv after 180 mins by PET imaging analysis
Drug uptake in midbrain of baboon neuroinflammation model assessed as drug distribution volume at 110 +/- 34 MBq, iv after 180 mins by PET imaging analysis
Drug uptake in temporal cortex of baboon neuroinflammation model assessed as drug distribution volume at 110 +/- 34 MBq, iv after 180 mins by PET imaging analysis
Drug uptake in parietal cortex of baboon neuroinflammation model assessed as drug distribution volume at 110 +/- 34 MBq, iv after 180 mins by PET imaging analysis
Drug uptake in cerebellum of baboon neuroinflammation model assessed as drug distribution volume at 110 +/- 34 MBq, iv after 180 mins by PET imaging analysis
Drug uptake in occipital cortex of baboon neuroinflammation model assessed as drug distribution volume at 110 +/- 34 MBq, iv after 180 mins by PET imaging analysis
Drug uptake in brainstem of baboon neuroinflammation model assessed as drug distribution volume at 110 +/- 34 MBq, iv administered 180 mins post 0.1 mpk LPS-challenge by PET imaging analysis
Drug uptake in midbrain of baboon neuroinflammation model assessed as drug distribution volume at 110 +/- 34 MBq, iv administered 180 mins post 0.1 mpk LPS-challenge by PET imaging analysis
Drug uptake in frontal cortex of baboon neuroinflammation model assessed as drug distribution volume at 110 +/- 34 MBq, iv administered 180 mins post 0.1 mpk LPS-challenge by PET imaging analysis
Drug uptake in temporal cortex of baboon neuroinflammation model assessed as drug distribution volume at 110 +/- 34 MBq, iv administered 180 mins post 0.1 mpk LPS-challenge by PET imaging analysis
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