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Effect on absolute power in alpha band in common marmoset at 0.3 to 3 mg/kg, po by electroencephalography analysis
Assay data:1 Tested
Summary
Antipsychotic-like activity in common marmoset assessed as induction of reduction in power in beta band at 1 mg/kg, po measured at 30 mins by electroencephalography analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, Active
Antipsychotic-like activity in common marmoset assessed as induction of increase in absolute power in delta band at 1 mg/kg, po measured at 30 mins by electroencephalography analysis
Antipsychotic-like activity in common marmoset assessed as induction of increase in theta band power at 3 mg/kg, po measured at 60 mins by electroencephalography analysis
Antipsychotic-like activity in common marmoset assessed as induction of increase in absolute power in delta band at 3 mg/kg, po measured between 30 and 120 mins by electroencephalography analysis
Sedative or hypnotic effect in marmoset assessed as number of animal jumps at 3 mg/kg, po dosed 2 hrs before test and measured over 2 mins post dose (Rvb = 22.3 +/- 2.5 No_unit)
Sedative or hypnotic effect in marmoset assessed as number of animal jumps at 1 mg/kg, po dosed 2 hrs before test and measured over 2 mins post dose (Rvb = 22.3 +/- 2.5 No_unit)
Sedative or hypnotic effect in marmoset assessed as number of animal jumps at 0.3 mg/kg, po dosed 2 hrs before test and measured over 2 mins post dose (Rvb = 22.3 +/- 2.5 No_unit)
Effect on animal postures in marmoset assessed as number of postures at 3 mg/kg, po dosed 2 hrs before test and measured over 2 mins post dose (Rvb = 12.2 +/- 0.3 No_unit)
Effect on animal postures in marmoset assessed as number of postures at 1 mg/kg, po dosed 2 hrs before test and measured over 2 mins post dose (Rvb = 12.2 +/- 0.3 No_unit)
Effect on animal postures in marmoset assessed as number of postures at 0.3 mg/kg, po dosed 2 hrs before test and measured over 2 mins post dose (Rvb = 12.2 +/- 0.3 No_unit)
Effect on animal postures in marmoset at 1 and 3 mg/kg, po dosed 2 hrs before test and measured over 2 mins post dose
Sedative or hypnotic effect in marmoset assessed as reduction in number of animal jumps at 1 and 3 mg/kg, po dosed 2 hrs before test and measured over 2 mins post dose
In vitro plasma protein binding (reported as Fu[%]) of 10,000 ng.ml-1 [14C] aliskiren hemifumarate in pooled plasma samples of marmoset
Total excretion of radioactivity following oral administration of [14C] aliskiren hemifumarate at 3 mg.Kg-1 level in marmoset
Total excretion of radioactivity following intravenous administration of [14C] aliskiren hemifumarate at 1 mg.Kg-1 level in marmoset
Excretion (0-72h) of aliskiren in faeces following oral administration of [14C] aliskiren hemifumarate at 3 mg.Kg-1 level in marmoset
Excretion (0-72h) of aliskiren in faeces following intravenous administration of [14C] aliskiren hemifumarate at 1 mg.Kg-1 level in marmoset
Excretion (0-168h) of radioactivity in faeces following oral administration of [14C] aliskiren hemifumarate at 3 mg.Kg-1 level in marmoset
Excretion (0-168h) of radioactivity in faeces following intravenous administration of [14C] aliskiren hemifumarate at 1 mg.Kg-1 level in marmoset
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