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Inhibition of snake venom NPP1 using bis(p-nitrophenyl)phosphate as substrate assessed as p-nitrophenol release preincubated for 30 mins by spectrophotometry
Assay data:20 Tested
SummaryPubMed Citation
Stability assessed as snake venom phosphodiesterase-mediated compound degradation at 5 nmol incubated for 180 mins by reversed-phase HPLC method
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of Serpentes (snake) phosphodiesterase using bis(p-nitrophenyl)phosphate as substrate at 500 uM incubated for 30 min prior to substrate addition by spectrophotometric analysis
Assay data:4 Tested
Summary
Stability of the compound assessed as snake venom phosphodiesterase-mediated initial rate of hydrolysis per microgram of protein at 50 uM by RP-HPLC analysis
Assay data:1 Active, 3 Tested
Inhibition of snake venom phosphodiesterase using bis-(para-nitrophenyl)phosphate as substrate at 0.2 mM after 30 min by spectrophotometric analysis
Assay data:5 Tested
Inhibition of snake venom phosphodiesterase using bis-(para-nitrophenyl)phosphate as substrate at 0.1 mM after 30 min by spectrophotometric analysis
Assay data:6 Tested
Inhibition of snake venom phosphodiesterase using bis-(para-nitrophenyl)phosphate as substrate after 30 min by spectrophotometric analysis
Assay data:2 Tested
Inhibition of Serpentes (snake) venom phosphodiesterase using bis(p-nitrophenyl)phosphate as substrate incubated for 30 min prior to substrate addition by spectrophotometric analysis
Assay data:1 Tested
Inhibition of snake venom phosphodiesterase-1 using bis-(p-nitropheny1) phosphate as substrate preincubated for 30 mins by spectrophotometry
Inhibition of snake venom NPP1 using bis(p-nitrophenyl)phosphate preincubated for 30 mins by spectrophotometry
Assay data:26 Tested
Inhibition of snake venom phosphodiesterase 1 using bis(p-nitrophenyl) phosphate substrate after 30 mins by spectrophotometry
Enzymatic stability was assessed with snake venom phosphodiesterase (SV PDE) exonuclase
Half life (t) of enzymatic phosphodiester hydrolysis of compound towards snake venom (SV-PDE) at a concentration of 4 microg
Biological half life period of compound was measured against snake venom phosphodiesterase (SVPDE)
Drug level treated with 1-O-[(guanosin-5'-yl)thiophosphyl]-2-S-[(guanosin-5'-yl)dithiophosphyl]-ethane assessed as snake venom phosphodiesterase-mediated compound formation at 50 uM after 15 mins by RP-HPLC analysis
Drug metabolism assessed as snake venom phosphodiesterase-mediated GMPS formation at 50 uM after 15 mins by RP-HPLC analysis
Drug level treated with (R,S)-P1,P3-di(adenosin-5'-yl)P1,P3- bis-thio-triphosphate assessed as snake venom phosphodiesterase-mediated compound formation at 50 uM after 30 mins by RP-HPLC analysis
Drug level treated with (S,S)-P1,P3-di(adenosin-5'-yl)P1,P3- bis-thio-triphosphate assessed as snake venom phosphodiesterase-mediated compound formation at 50 uM after 2 hrs by RP-HPLC analysis
Drug metabolism assessed as snake venom phosphodiesterase-mediated (Sp)-ADPalphaS formation at 50 uM after 30 mins by RP-HPLC analysis
Drug metabolism assessed as snake venom phosphodiesterase-mediated (Sp)-ADPalphaS formation at 50 uM after 2 hrs by RP-HPLC analysis
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