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Inhibition of NADH-Fumarate reductase in Ascaris suum muscle sub-mitochondrial particles using disodium fumarate as substrate in presence of NADH after 3 mins measured every 15 sec for 10 mins under anaerobic condition
Assay data:7 Active, 6 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of electron transport protein complex 1 in Ascaris suum mitochondria assessed as reduction in rhodoquinol-fumarate reductase activity by measuring NADH oxidation using NADH, sodium fumarate and decyl-rhodoquinone
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
Inhibition of Ascaris suum eIF4E-3 assessed as inhibition of cap-dependent translation after 1 hr by cell-free Renilla luciferase reporter gene assay
Assay data:8 Active, 1 Activity ≤ 1 µM, 16 Tested
Inhibition of Ascaris suum NADH fumarate reductase
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Compound was evaluated for inhibition of binding to Ascaris suum AF2 neuropeptide receptor
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Ratio of m7GTP IC50 to compound IC50 for Ascaris suum eIF4E-3 assessed as inhibition of cap-dependent translation after 1 hr by cell-free Renilla luciferase reporter gene assay
Assay data:1 Tested
SummaryPubMed Citation
Antiparasitic activity against L3 and L4 larval stages of Ascaris suum
Inhibition of Ascaris suum T6PP assessed as Km for substrate using T6P as substrate by Lineweaver-Burk plot analysis
Assay data:4 Tested
Inhibition of Ascaris suum T6PP assessed as Vmax for substrate using T6P as substrate by Lineweaver-Burk plot analysis
Activity at Ascaris suum T6PP
Inhibition of Ascaris suum T6PP using T6P as substrate assessed as fraction of enzyme unbound with compound by measuring ratio of initial velocities of T6P substrate hydrolysis in presence and absence of compound at 1 mM after 5 mins by BioMol green dye based HTS assay
Assay data:34 Tested
Inhibition of Ascaris suum T6PP using T6P as substrate by Lineweaver-Burk plot analysis
Assay data:6 Tested
Effect on succinate formation by isolated Ascaris suum mitochondria at a concentration of 50 uM
Effect on succinate formation by isolated Ascaris suum mitochondria at a concentration of 3 uM
Effect on succinate formation by isolated Ascaris suum mitochondria at a concentration of 25 uM
Effect on succinate formation by isolated Ascaris suum mitochondria at a concentration of 200 uM
Effect on succinate formation by isolated Ascaris suum mitochondria at a concentration of 10 uM
Effect on succinate formation by isolated Ascaris suum mitochondria at a concentration of 0 uM
Effect on incorporation of [32Pi] by isolated Ascaris suum mitochondria at a concentration of 50 uM.
Effect on incorporation of [32Pi] by isolated Ascaris suum mitochondria at a concentration of 3 uM
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