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Antischistosomal activity against Schistosoma haematobium assessed as inhibition of parasite movement at 100 nM measured after 24 to 72 hrs by microscopic method
Assay data:3 Active, 4 Tested
SummaryCompounds, ActivePubMed Citation
Antischistosomal activity against Schistosoma haematobium assessed as worm death at 10 uM incubated for 96 hrs relative to control
Assay data:1 Tested
SummaryPubMed Citation
Antischistosomal activity against Schistosoma haematobium assessed as worm death at 10 uM incubated for 120 hrs relative to control
Assay data:3 Tested
Antischistosomal activity against Schistosoma haematobium assessed as worm death at 10 uM incubated for 144 hrs relative to control
Antischistosomal activity against Schistosoma haematobium at 10 uM measured after 72 hrs relative to control
Assay data:11 Tested
Antischistosomal activity against Schistosoma haematobium Egyptian infected in NMRI mouse assessed as worm burden reduction at 200 mg/kg, po measured after 14 days
Antischistosomal activity against adult Schistosoma haematobium assessed as reduction in worm viability at 100 uM measured after 48 hrs by microscopic method relative to control
Antischistosomal activity against adult Schistosoma haematobium assessed as reduction in worm viability at 100 uM measured after 4 hrs by microscopic method relative to control
Concentration required to kill 50% of 84 day old worms 5 days after drug treatment.
Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antischistosomal activity against Schistosoma haematobium imago derived from infected mouse at 20 ug/ml after 72 hrs
Assay data:6 Tested
Antischistosomal activity against Schistosoma haematobium infected in mouse assessed as reduction in adult worm burden at 400 mg/kg, po administered as single dose relative to control
Antischistosomal activity against Schistosoma haematobium infected in golden syrian hamster assessed as worm killing at 143 uM pretreated for 45 mins followed by compound washout measured after 14 days
Assay data:18 Tested
Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB
Assay data:3916 Active, 206 Activity ≤ 1 nM, 1830 Activity ≤ 1 µM, 3916 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Experimentally measured binding affinity data derived from PDB
Assay data:3073 Active, 3073 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
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