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Inhibition of Plasmodium knowlesi DHFR
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of recombinant Plasmodium knowlesi SUB1 using SERA4st1F-6R1 as substrate by fluorescence spectrophotometer
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of recombinant C-terminal 6-His tagged Plasmodium knowlesi SUB1 expressed in baculovirus expression system
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Antiplasmodial activity against Plasmodium knowlesi infected in human erythrocytes assessed as inhibition of parasite growth incubated for 72 hrs in presence of 1 uM pantothenate by SYBR Green I dye based fluorescence assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Antimalarial activity against asexual blood stage of Plasmodium knowlesi YHI assessed as reduction in cell viability after 48 hrs by EtBr staining based flow cytometric analysis
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
Growth inhibition of Plasmodium knowlesi YH1 after 50 hrs by ethidium bromide staining based flow cytometry
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Growth inhibition of Plasmodium knowlesi YH1 after 90 hrs by ethidium bromide staining based flow cytometry
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of Plasmodium knowlesi recombinant His6-tagged GSK-3 expressed in Escherichia coli using GS-1 peptide as substrate after 30 mins by scintillation counting analysis in presence of gamma-33P-ATP
Assay data:4 Active, 6 Tested
Antimalarial activity against Plasmodium knowlesi infected in rhesus monkey RBC assessed as [3H]-hypoxanthine incorporation after 12 hrs by scintillation counting
Assay data:5 Active, 2 Activity ≤ 1 µM, 13 Tested
Antimalarial activity against Plasmodium knowlesi infected Chinese rhesus macaques assessed as parasitemia level in blood smears at 40 mg/kg, intragastric treated 5 days before infection measured between day 0 to 7 by Giemsa-staining in presence of ritonavir 5 mg/kg, intragastric twice daily
Antimalarial activity against Plasmodium knowlesi infected Chinese rhesus macaques assessed as parasitemia level in blood smears at 40 mg/kg, intragastric treated 5 days before infection measured between day 0 to 7 by Giemsa-staining in presence of ritonavir 10 mg/kg, intragastric once daily
Assay data:1 Tested
SummaryPubMed Citation
Antimalarial activity as parasite elimination after 24 hrs against Plasmodium knowlesi infected Rhesus monkey at 30 mg/kg intravenous dose
Antimalarial activity as parasite elimination up to day 50 against Plasmodium knowlesi infected Rhesus monkey at 30 mg/kg intravenous dose over 3 days
Antimalarial activity as cures at day 50 in Plasmodium knowlesi infected Rhesus monkey assessed at 15 mg/kg intravenous dose for 3 days
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