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OSM: Inhibition of Plasmodium falciparum K1 growth. IC50 values determined from 21 point dose response curves. Avery Group Griffith.
Assay data:6 Active, 1 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
OSM: CSIR assay K1: Compounds were tested for inhibition of Plasmodium falciparum growth using a SYBR green I fluorescence based assay.
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
OSM: Percent inhibition of Plasmodium falciparum K1 growth at 120 uM. Avery Group Griffith.
Assay data:10 Tested
Summary
WHO-TDR: Malaria
Assay data:740 Tested
TBD from US Patent US11530198: "Compositions and methods for treating infections"
Assay data:6 Active, 2 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Parasite Proliferation Assay from Article 10.1038/nchembio.87: "Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility."
Assay data:12 Active, 10 Activity ≤ 1 µM, 15 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Scintillation Proximity Assay from Article 10.1038/nchembio.87: "Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility."
Assay data:14 Active, 10 Activity ≤ 1 µM, 14 Tested
Antimalarial Testing In Vitro (IC50) and Measurement of Inhibition Constant (Ki) from Article 10.1038/nsb921: "Insights into antifolate resistance from malarial DHFR-TS structures."
Assay data:3 Active, 3 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Plasmodium falciparum PFPK5 assessed as percent of control at 2000 nM by KINOMEscan assay relative to control
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of DNA-tagged Plasmodium falciparum PFPK5 assessed as percent of control at 50000 nM by qPCR analysis relative to control
Inhibition of Plasmodium falciparum PFPK5 assessed as percent of control at 1000 nM by KINOMEscan assay relative to control
Inhibition of CRT CVIET haplotype mutant in Plasmodium falciparum K1 isolate MRA-159 infected in erythrocytes assessed as reversal of chloroquine resistance by measuring reduction in chloroquine IC50 by Hoechst 33342 staining based flow cytometry
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of CRT CVIET haplotype mutant in chloroquine-resistant Plasmodium falciparum K1 isolate MRA-159 assessed as reversal of chloroquine resistance by measuring reduction in chloroquine IC50 relative to chloroquine alone
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of Plasmodium falciparum DHFR using DHF as substrate preincubated for 15 mins followed DHF addition measured after 15 mins by spectrophotometric method
Assay data:20 Active, 20 Activity ≤ 1 µM, 24 Tested
Inhibition of Plasmodium falciparum DHFR
Assay data:8 Active, 2 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 9 Tested
Inhibition of Plasmodium falciparum PFPK5 assessed as residual activity at 10 uM relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Plasmodium falciparum PFPK5 at 10 uM
Assay data:2 Tested
Inhibition constant against Plasmodium falciparum dihydrofolate reductase
Assay data:50 Active, 10 Activity ≤ 1 nM, 43 Activity ≤ 1 µM, 52 Tested
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