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Biological Assay from US Patent US12017994: "Compounds, compositions, and methods for selectively inhibiting β-glucuronidases and alleviating side effects associated with drug treatment induced diarrhea"
Assay data:11 Active, 5 Activity ≤ 1 µM, 16 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
SDFQ HTS Assay from US Patent US20230364057: "BACTERIAL DNA GYRASE INHIBITORS AND METHODS OF USE THEREOF"
Assay data:19 Active, 79 Tested
SummaryCompounds, Active
Isothermal Titration Calorimetry (ITC) from US Patent US11802110: "2-amino-N-(arylsulfinyl)-acetamide compounds as inhibitors of bacterial aminoacyl-tRNA synthetase"
Assay data:24 Active, 22 Activity ≤ 1 µM, 24 Tested
Enzyme Inhibition Assay from US Patent US11590142: "Oxazolidinone antibiotic compounds and process of preparation"
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Depositor
Inhibition Assay from US Patent US11572337: "Antibacterial agents: arylalkylcarboxamido phloroglucinols"
Assay data:42 Active, 25 Activity ≤ 1 µM, 44 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
MCL-1/Noxa BH3 Peptide (MCL-1 Assay) from US Patent US11478451: "Macrocyclic chlorine substituted indole derivatives"
Assay data:61 Active, 3 Activity ≤ 1 nM, 61 Activity ≤ 1 µM, 61 Tested
MCL-1/Noxa BH3 Peptide (MCL-1 Assay) from US Patent US11447504: "Macrocyclic chlorine substituted indole derivatives"
Assay data:49 Active, 21 Activity ≤ 1 nM, 49 Activity ≤ 1 µM, 49 Tested
Protein-Protein Interaction Assay: MCL-1/Noxa BH3 Peptide (MCL-1 Assay) from US Patent US11440923: "Substituted macrocyclic indole derivatives"
Assay data:79 Active, 35 Activity ≤ 1 nM, 79 Activity ≤ 1 µM, 79 Tested
LpxC Binding Assay from US Patent US11407740: "Antibacterial compounds"
Assay data:58 Active, 58 Activity ≤ 1 µM, 58 Tested
Inhibition of Beta-Lactamase Enzymes from US Patent US10800778: "Beta-lactamase inhibitor compounds"
Assay data:39 Active, 1 Activity ≤ 1 nM, 38 Activity ≤ 1 µM, 40 Tested
Assay of Inhibition of Escherichia coli RNA Polymerase from US Patent US10800725: "Arylpropionyl-triketone antibacterial agents"
Assay data:16 Active, 7 Activity ≤ 1 µM, 20 Tested
Test for beta-lactamase Inhibitory Activity from US Patent US10544146: "Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors"
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition Assay from US Patent US9422297: "Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof"
Assay data:13 Active, 6 Activity ≤ 1 µM, 27 Tested
β-Glucuronidase Inhibition Assay from Article 10.3109/14756366.2011.590804: "Biotransformation of dehydroepiandrosterone with Macrophomina phaseolina and -glucuronidase inhibitory activity of transformed products."
Assay data:6 Tested
SummaryPubMed CitationRelated BioAssays by Target
Aminoacylation Assay from Article 10.1074/jbc.M114.574061: "The role of a novel auxiliary pocket in bacterial phenylalanyl-tRNA synthetase druggability."
Assay data:12 Active, 10 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition Kinetics Assay from Article 10.1074/jbc.M113.532804: "Rational design of broad spectrum antibacterial activity based on a clinically relevant enoyl-acyl carrier protein (ACP) reductase inhibitor."
Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
RNAP-Inhibition Assay from Article 10.1021/acschembio.6b01133: "Affinity Selection-Mass Spectrometry Identifies a Novel Antibacterial RNA Polymerase Inhibitor."
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
In Silico Screening from Article 10.1002/cbic.201700052: "Spectroscopic and Computational Investigations of Ligand Binding to IspH: Discovery of Non-diphosphate Inhibitors."
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Fluorescence Polarization Assay from Article 10.1074/jbc.M114.564278: "Structural basis for the recognition of peptide RJPXD33 by acyltransferases in lipid A biosynthesis."
Assay data:6 Active, 2 Activity ≤ 1 µM, 8 Tested
Kinetic Assay from Article 10.1074/jbc.M113.533562: "The different inhibition mechanisms of OXA-1 and OXA-24 -lactamases are determined by the stability of active site carboxylated lysine."
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