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Inhibition of TGFBR1/TGFBR2 protein-protein interaction in MLEC cells assessed as inhibition of TGF-beta1-induced dimer formation preincubated for 30 mins followed by TGF-beta1-stimulation and measured after overnight by pathhunter assay
Assay data:1 Tested
SummaryPubMed Citation
Inhibition of TGFbeta signalling pathway in MLEC preincubated for 30 mins followed by TGF-beta1 addition and measured after 18 hrs by Steady-Glo luciferase assay
Assay data:1 Active, 11 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of TGFbetaR1 in TGFbeta-stimulated mink Mv1Lu cells assessed as reduction in SMAD nuclear translocation preincubated for 1 hr followed by TGFbeta-stimulation for 15 mins by array scan based method
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of TGFbetaR1 in mink Mv1Lu cells assessed as reduction in TGFbeta-stimulated TSMAD nuclear translocation preincubated for 1 hr followed by TGFbeta addition measured after 15 mins
Assay data:10 Active, 7 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of TGFbetaR1 in mink Mv1Lu cells assessed as TGFbeta-stimulated PSMAD2 phosphorylation preincubated for 1 hr followed by TGFbeta addition measured after 15 mins
Assay data:18 Active, 16 Activity ≤ 1 µM, 20 Tested
Inhibition of HDAC in mink Mv1Lu cells expressing human wild-type p21 promoter luciferase fusion plasmid assessed as drug level inducing 10-fold higher luciferase activity by p21 promoter assay relative to baseline
Assay data:8 Active, 7 Activity ≤ 1 µM, 8 Tested
Increase in human wild type p21 protein expression in mink Mv1Lu cells after 24 hrs by p21 promoter assay in presence of 0.1 mM dithiothreitol
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Increase in human wild type p21 protein expression in mink Mv1Lu cells after 24 hrs by p21 promoter assay
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
Antiproliferative activity against mink Mv1Lu-p3TP-Lux cells by luciferase reporter assay
Assay data:18 Active, 17 Activity ≤ 1 µM, 27 Tested
Inhibition of TNF-beta-induced AP1 activation in mink Mv1Lu epithelial cells
Induction of wild-type p21 promoter activation in mink Mv1Lu cells after 18 hrs by luciferase assay relative to basal level
Assay data:13 Active, 11 Activity ≤ 1 µM, 14 Tested
Cytotoxicity against MLEC assessed as reduction in cell viability at 50 uM by MTT assay
Assay data:10 Tested
Inhibition of TGFbeta signaling in mink C32 cells at 10 uM by luciferase based assay
Assay data:1 Active, 1 Tested
Cytotoxicity against mink CCL64 cells upto 100 uM after 72 hrs by MTT assay in presence of 0.2% fetal bovine serum
Assay data:3 Tested
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