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Antifungal activity against Cryptococcus neoformans var. neoformans after 48 hr by broth microdilution method
Assay data:1 Active, 14 Tested
SummaryCompounds, Active
Antimicrobial activity against Cryptococcus neoformans var. neoformans isolate 25 after 48 hrs by microdilution broth method
Assay data:15 Tested
SummaryPubMed Citation
Antimicrobial activity against Cryptococcus neoformans var. neoformans isolate 30 after 48 hrs by microdilution broth method
Antimicrobial activity against Cryptococcus neoformans var. neoformans isolate 27 after 48 hrs by microdilution broth method
Antimicrobial activity against Cryptococcus neoformans var. neoformans isolate 14 after 48 hrs by microdilution broth method
Antimicrobial activity against Cryptococcus neoformans var. neoformans by broth microdilution method
Assay data:9 Tested
Antifungal activity against Cryptococcus neoformans var. neoformans by EUCAST method
Assay data:5 Tested
Antifungal activity against Cryptococcus neoformans var. neoformans
Antimicrobial activity against Cryptococcus neoformans var.neoformans serotype D ATCC 28952 by broth microdilution method
Assay data:16 Tested
Thymidylate Synthase (TS) Assay from Article 10.1021/jm051187d: "Antibacterial agent discovery using thymidylate synthase biolibrary screening."
Assay data:17 Active, 9 Activity ≤ 1 µM, 19 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Thymidylate Synthase (TS) Assay from Article 10.1107/S0907444905022638: "The structure of Cryptococcus neoformans thymidylate synthase suggests strategies for using target dynamics for species-specific inhibition."
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Uncompetitive inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 0.156 uM assessed as Km for substrate using NAD as fixed substrate at 700 uM and IMP as second substrate with varying concentrations of 25 to 800 uM (Rvb = 257.5 +/- 23 microM)
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Uncompetitive inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) at 0.156 uM assessed as Km for substrate using IMP as fixed substrate at 500 uM and NAD as second substrate with varying concentrations of 31.25 to 1300 uM (Rvb = 257.5 +/- 23 microM)
Inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) using IMP as substrate in presence of NAD
Assay data:16 Active, 13 Activity ≤ 1 µM, 16 Tested
Inhibition of Cryptococcus neoformans thymidylate synthase
Assay data:13 Active, 2 Activity ≤ 1 µM, 18 Tested
Inhibition of Cryptococcus neoformans H99 PLB1activity
Assay data:4 Active, 14 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Kinetic constant for the inhibition of imidazole glycerol phosphate dehydratase (IGPD)
Assay data:18 Active, 1 Activity ≤ 1 µM, 24 Tested
Binding affinity imidazole glycerol phosphate dehydratase (IGPD) obtained from Cryptococcus neoformans
Assay data:26 Active, 1 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 26 Tested
Inhibitory concentration against imidazole glycerol phosphate dehydratase (IGPD) from Cryptococcus neoformans
Assay data:22 Active, 6 Activity ≤ 1 µM, 29 Tested
Inhibition of recombinant Cryptococcus neoformans His-tagged IMPDH expressed in Escherichia coli BL21 (DE3) using IMP as substrate and DTT containing buffer in presence of NAD
Assay data:2 Tested
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