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Binding affinity to castor beans ricin toxin A subunit assessed as dissociation constant by surface plasmon resonance analysis
Assay data:14 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of castor bean ricin mediated depurination activity African green monkey Vero cells toxin pretreated for 2 hrs at 500 uM measured after 2 hrs of cell addition by qRT-PCR analysis
Assay data:5 Tested
Inhibition of castor bean ricin mediated depurination activity African green monkey Vero cells toxin pretreated for 2 hrs at 250 uM measured after 2 hrs of cell addition by qRT-PCR analysis
Maximal inhibition of castor beans ricin toxin A subunit assessed as depurination of ribosome using yeast ribosomes by qRT-PCR analysis
Assay data:4 Tested
Inhibition of castor beans ricin toxin A subunit assessed as depurination of ribosome using yeast ribosomes by qRT-PCR analysis
Potency index, ratio of CC10501 to test compound IC50 for inhibition of castor beans ricin toxin A subunit assessed as depurination of ribosome using yeast ribosomes by qRT-PCR analysis
Inhibition of castor beans ricin toxin A subunit assessed as depurination of ribosome using yeast ribosomes at 100 uM by qRT-PCR analysis
Inhibition of castor beans ricin toxin A subunit assessed as depurination of ribosome using liver ribosomes by qRT-PCR analysis
Assay data:1 Tested
Binding affinity to castor beans ricin toxin A subunit assessed as dissociation constant
Inhibition of Populus sieboldii x Populus grandidentata trans-cinnamate 4-hydroxylase assessed as p-coumaric acid level
Assay data:4 Active, 1 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of Populus sieboldii x Populus grandidentata trans-cinnamate 4-hydroxylase expressed in Saccharomyces cerevisiae BJ2168 assessed as inhibition of hydroxylation of cinnamic acid after 60 min
Assay data:18 Active, 11 Activity ≤ 1 µM, 30 Tested
Inhibition of castor bean ricin-induced toxicity in human A549 cells assessed as protection against toxin-induced inhibition of protein biosynthesis by measuring incorporation of [14C]-leucine into cells preincubated for 1 hr followed by toxin challenge measured after 20 hrs by liquid scintillation counting analysis
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of castor bean ricin toxin A after 90 mins by luciferase reporter gene assay
Inhibition of Ricin toxin A after 90 mins by luciferase-translational assay
Assay data:1 Active, 15 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Ricinus communis ricin toxin A after 90 mins by luciferase reporter gene assay
Assay data:16 Tested
Compound was tested for binding affinity against hydroxynitrile lyase.
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Compound was tested for binding affinity against hydroxynitrile lyase
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Mixed-type inhibition of Populus sieboldii x Populus grandidentata trans-cinnamate 4-hydroxylase by Lineweaver-Burk plot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of Viola arvensis protoporphyrinogen oxidase by post-emergence herbicidal activity assay
Assay data:3 Tested
Summary
Ratio of 7-carboxypterin IC50 to compound IC50 for Ricinus communis ricin toxin A
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