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Kinase Assay from US Patent US20240199649: "4-AMINOPYRROLO[2,1-F][1,2,4]TRIAZINES AND PREPARATION AND USES THEREOF"
Assay data:158 Active, 42 Activity ≤ 1 nM, 157 Activity ≤ 1 µM, 158 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
GTP-KRAS and cRAF Interaction Assay from US Patent US20240199644: "Fused Ring Derivatives Useful as KRAS G12D Inhibitors"
Assay data:16 Active, 4 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 16 Tested
Binding Assay from US Patent US20240199635: "TETRAHYDROTHIENO PYRIDINE DERIVATIVES AS DDRS INHIBITORS"
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
HASPIN biochemical Assay from US Patent US20240199630: "IMIDAZO[1,2-B]PYRIDAZINE BASED TRICYCLIC COMPOUNDS AS INHIBITORS OF HASPIN AND THERAPEUTIC USES THEREOF"
Assay data:21 Active, 21 Activity ≤ 1 µM, 21 Tested
Homogeneous Time-Resolved Fluorescence (HTRF) from US Patent US20240199625: "BICYCLIC HETEROCYCLIC FGFR4 INHIBITOR, PHARMACEUTICAL COMPOSITION AND PREPARATION COMPRISING SAME, AND APPLICATION THEREOF"
Assay data:8 Active, 3 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested
Binding assay NK-2 from US Patent US20240199618: "NOVEL N-ACYL-[3-SUBSTITUTED]-[8-SUBSTITUTED]-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR-MEDIATED DISORDERS"
Assay data:1 Active, 42 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
Binding assay NK-1 from US Patent US20240199618: "NOVEL N-ACYL-[3-SUBSTITUTED]-[8-SUBSTITUTED]-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR-MEDIATED DISORDERS"
Assay data:42 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
Binding Competition Assay with Human NK-3 Receptor from US Patent US20240199618: "NOVEL N-ACYL-[3-SUBSTITUTED]-[8-SUBSTITUTED]-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-a]PYRAZINES AS SELECTIVE NK-3 RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITION, METHODS FOR USE IN NK-3 RECEPTOR-MEDIATED DISORDERS"
Assay data:45 Active, 45 Activity ≤ 1 µM, 45 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
SHP2 Allosteric Inhibition Assay from US Patent US20240199616: "BICYCLIC COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS"
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
Inhibition of auto-phosphorylation of recombinant human NF-kappaB-inducing kinase (NIK/MAP3K14) activity (AlphaScreen) from US Patent US20240199605: "SMALL MOLECULAR INHIBITORS OF NF-kB INDUCING KINASE"
Assay data:298 Active, 112 Activity ≤ 1 nM, 280 Activity ≤ 1 µM, 302 Tested
hERG Qpatch Assay Protocol from US Patent US20240199576: "NOVEL CYCLOPENTA[C]PYRROL NEGATIVE ALLOSTERIC MODULATORS OF NR2B"
Assay data:3 Active, 5 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Evaluation of Enzyme Activity from US Patent US20240199571: "THIOPHENE COMPOUND AND APPLICATION THEREOF"
Assay data:88 Active, 88 Activity ≤ 1 µM, 88 Tested
ADP-Glo Assay Promega from US Patent US20240199561: "INHIBITORS OF DYRK AND PIM"
Assay data:17 Active, 17 Activity ≤ 1 µM, 17 Tested
[35S]-GTPγS Binding Assay from US Patent US20240199558: "2,4,6-TRISUBSTITUTED 1,3,5-TRIAZINES AS MODULATORS OF CX3CR1"
Assay data:159 Active, 137 Activity ≤ 1 µM, 165 Tested
Radioligand Binding Assay from US Patent US20240199555: "APPLICATIONS OF BIASED LIGANDS OF THE SEROTONIN 5-HT7 RECEPTOR FOR THE TREATMENT OF PAIN, MULTIPLE SCLEROSIS AND THE CONTROL OF THERMOREGULATION"
Assay data:29 Active, 7 Activity ≤ 1 nM, 28 Activity ≤ 1 µM, 29 Tested
Human DHODH Inhibition Assay from US Patent US20240199535: "DEUTERATED DHODH INHIBITORS"
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
Phosphatase (PTPase) Assay from US Patent US20240199525: "SHP2-Targeting Small Molecules For Use As Anti-Cancer Agents"
Assay data:6 Active, 2 Activity ≤ 1 µM, 10 Tested
Surface Plasmon Resonance Assay from US Patent US20240197735: "METHODS AND COMPOSITIONS COMPRISING A BRAF INHIBITOR AND A PD-1 BINDING ANTAGONIST"
Assay data:4 Active, 2 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Competitive FP Binding Assay from US Patent US12012467: "Small molecule DCN1 inhibitors and therapeutic methods using the same"
Assay data:207 Active, 175 Activity ≤ 1 µM, 277 Tested
Fluorescence Assay from US Patent US12012394: "Alpha-synuclein ligands"
Assay data:10 Active, 17 Activity ≤ 1 µM, 17 Tested
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