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Inhibition of sea urchin egg fertilization after 10 mins
Assay data:10 Tested
SummaryPubMed Citation
Antimitotic activity against sea urchin eggs assessed as inhibition of egg development at first cleavage
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antimitotic activity against sea urchin eggs assessed as inhibition of development at second cleavage
Antimitotic activity against sea urchin eggs assessed as inhibition of egg development at blastulation stage
Antagonistic activity at NAADP receptor in sea urchin egg homogenate assessed as inhibition of NAADP-mediated Ca2+ release using Fluo-3 staining based fluorimetric assay relative to control
Assay data:6 Active, 2 Activity ≤ 1 µM, 27 Tested
Displacement of [32P]NAADP from NAADP receptor in sea urchin egg homogenate preincubated 10 mins before [32P]NAADP addition
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 2 Tested
Displacement of [32P]NAADP from Egg-binding protein in sea urchin egg homogenate at 6 uM after 10 mins
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of SERCA in sea urchin eggs assessed as Ca2+ leak rate at 10 uM relative to thapsigargin
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Antagonist activity at ryanodine receptor in sea urchin egg homogenates assessed as decrease in cADPcR-induced calcium release by fluorimetry
Assay data:4 Tested
Agonist activity at ryanodine receptor in sea urchin egg homogenates assessed as effect on calcium release by fluorimetry
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Antagonist activity at cADPR receptor in sea urchin egg homogenates assessed as inhibition of calcium release
Concentration response relationship was used to measure half-maximally effective agonist concentration.
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Antagonistic activity at NAADP receptor in intact sea urchin eggs assessed as Inhibition of NAADP mediated Ca2+ increase at 100 uM using Oregon Green 488-BAPTA Dextran staining based by laser scanning confocal microscopy
Displacement of [32P]NAADP from NAADP receptor in sea urchin egg homogenate after 5 days
Noncompetitive inhibition of NAADP receptor in sea urchin egg homogenate assessed as inhibition of NAADP induced Ca2+ release using Fluo-3 staining based fluorimetric assay
Antimitotic activity in Lytechinus variegatus embryo assessed as inhibition of blastula formation at 370 uM relative to control
Assay data:1 Tested
Antimitotic activity in Lytechinus variegatus embryo assessed as inhibition of blastula formation at 37 uM relative to control
Antimitotic activity in Lytechinus variegatus embryo assessed as inhibition of blastula formation at 417 uM relative to control
Assay data:3 Tested
Antimitotic activity in Lytechinus variegatus embryo assessed as inhibition of blastula formation at 41.7 uM relative to control
Antimitotic activity in Lytechinus variegatus embryo assessed as inhibition of blastula formation at 394 uM relative to control
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