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Toxicity in ferret assessed as induction of retching at 0.5 mg/kg, sc measured for 60 mins
Assay data:1 Tested
SummaryPubMed Citation
Toxicity in ferret assessed as induction of licking behavior at 0.5 mg/kg, sc measured 2.20 mins post injection
Toxicity in ferret assessed as backward walking episodes at 0.5 mg/kg, sc measured 2.20 mins post injection
Toxicity in ferret assessed as reduction in locomotor behavior at 0.5 mg/kg, sc measured 1.05 mins to 1 hr post injection
Toxicity in ferret assessed as cessation of movement at 0.5 mg/kg, sc measured for 60 mins
Toxicity in ferret assessed as increase in breathing at 0.5 mg/kg, sc measured for 60 mins
Toxicity in ferret assessed as induction of emetic episodes at 0.5 mg/kg, sc measured for 60 mins
Positive inotropic activity in ferret papillary muscle assessed as contractile force measured as CFC20
Assay data:3 Active, 2 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Prodrug conversion in ferret lung assessed as triphosphate metabolite formation at 10 mg/kg, iv measured after 24 hrs
Prodrug conversion in ferret assessed as AUC (0 to last) of parent nucleoside compound at 10 mg/kg, iv
AUC (0 to infinity) in ferret at 10 mg/kg, iv
Volume of distribution at steady state in ferret at 10 mg/kg, iv
Half life in ferret at 10 mg/kg, iv
Clearance in ferret at 10 mg/kg, iv
AUC total in ferret at 3.42 umol/kg, ig
Assay data:2 Tested
Cmax in ferret at 0.3 mg/kg, po
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Cmax in ferret at 0.1 mg/kg, po
Cmax in ferret at 2 mg/kg, po
Antiemetic activity against cisplatin-induced emesis in sc dosed ferrets
Assay data:13 Tested
Plasma concentration in ferret
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