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The drug is tested on Clostridium difficile strain: 120 for biotransformation. The drug concentrations were measured before and after a 12-h incubation by liquid-chromatography-coupled mass spectrometry (LC?MS)
Assay data:195 Tested
SummaryPubMed Citation
Invivo Antibacterial activity against Clostridium difficile infected in hamster assessed as survival at 50 mg/kg, sc relative to control
Assay data:3 Tested
Antibacterial activity against Clostridium difficile 2004118 strain assessed as bacterial growth inhibition incubated for 48 hrs by agar dilution method
Assay data:1 Tested
Antibacterial activity against Clostridium difficile NAP1/027/BI-type strain 2009155 assessed as bacterial growth inhibition incubated for 48 hrs by agar dilution method
Antibacterial activity against Clostridium difficile ATCC 43255 strain assessed as bacterial growth inhibition incubated for 48 hrs by agar dilution method
Antibacterial activity against Clostridium difficile NCTC 11223 strain assessed as bacterial growth inhibition incubated for 48 hrs by agar dilution method
Antibacterial activity against Clostridium difficile ATCC 43596 strain assessed as bacterial growth inhibition incubated for 48 hrs by agar dilution method
Antibacterial activity against Clostridium difficile B1 SM8-6865 infected in Syrian golden hamster CDAD model assessed as reduction in bacterial count in cecum at 1.56 mg/kg,po qd for 4 days and measured after 24 hrs last dose
Antibacterial activity against Clostridium difficile B1 SM8-6865 infected in Syrian golden hamster CDAD model assessed as reduction in bacterial count in cecum at 6.25 to 12.5 mg/kg,po qd for 4 days and measured after 24 hrs last dose
Antibacterial activity against Clostridium difficile B1 SM8-6865 infected in Syrian golden hamster CDAD model assessed as survival at 1.56 mg/kg,po qd for 4 days
Antibacterial activity against Clostridium difficile B1 SM8-6865 infected in Syrian golden hamster CDAD model assessed as survival at 6.25 to 12.5 mg/kg,po qd for 4 days
Antibacterial activity against wild type Clostridium difficile incubated for 20 hrs by two-fold serial dilution method
Antibacterial activity against Clostridioides difficile
Assay data:5 Tested
Antibacterial activity against Clostridioides difficile ATCC BAA 1870 assessed as inhibition of bacterial growth incubated for 18 to 20 hrs by CLSI protocol based broth microdilution method
Antibacterial activity against Clostridium difficile at 0.5 % measured after 8 mins by broth microdilution analysis
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Antibacterial activity against Clostridium difficile assessed as bacterial growth inhibition incubated for 24 hrs
Potency index, ratio of vancomycin MIC to test compound MIC for antibacterial activity against Clostridium difficile ATCC 43255 assessed as inhibition of bacterial growth by standard broth microdilution susceptibility method
Assay data:2 Tested
Antibacterial activity against Clostridium difficile ATCC 43255 assessed as inhibition of bacterial growth by standard broth microdilution susceptibility method
Assay data:18 Tested
Antibacterial activity against Clostridium difficile CECT531 incubated for 24 hrs by CLSI based broth microdilution method
Assay data:1 Active, 38 Tested
Antibacterial activity against Clostridioides difficile BAA 1382
Assay data:7 Tested
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