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HIV Protease Enzyme Inhibition (PI) Activity Assay from US Patent US11352329: "HIV protease inhibitors"
Assay data:347 Active, 345 Activity ≤ 1 µM, 347 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
FRET-Based RNase H Assay from Article 10.1021/cb8001039: "Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity."
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Assay of RT RNA-Dependent DNA Polymerase (RDDP) Activity from Article 10.1021/cb600303y: "HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site."
Assay data:4 Active, 3 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Assay of RT RNH Activity from Article 10.1021/cb600303y: "HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site."
Assay data:6 Active, 1 Activity ≤ 1 µM, 9 Tested
HIV-1 RT Enzyme Assay from Article 10.1021/jm060103d: "Synthesis, Biological Activity, and Crystal Structure of Potent Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase That Retain Activity against Mutant Forms of the Enzyme."
Assay data:9 Active, 5 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
HIV-1 RT Assay from Article 10.1021/jm0613121: "De Novo Parallel Design, Synthesis and Evaluation of Inhibitors against the Reverse Transcriptase of Human Immunodeficiency Virus Type-1 and Drug-Resi"
Assay data:5 Active, 28 Tested
HIV-1 RT Assay from Article 10.1016/j.bmcl.2003.11.049: "Novel nevirapine-like inhibitors with improved activity against NNRTI-resistant HIV: 8-heteroarylthiomethyldipyridodiazepinone derivatives."
Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested
HIV-1 RT Assay from Article 10.1021/jm9707028: "Novel nonnucleoside inhibitors of HIV-1 reverse transcriptase. 7. 8-Arylethyldipyridodiazepinones as potent broad-spectrum inhibitors of wild-type and mutant enzymes."
Assay data:53 Active, 56 Activity ≤ 1 µM, 57 Tested
HIV-1 RT Assay from Article 10.1021/jm7015057: "Thermodynamic and structure guided design of statin based inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase."
Assay data:12 Active, 12 Activity ≤ 1 µM, 12 Tested
HIV-1 RT Assay from Article 10.1021/jm9707030: "Novel Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase. 8. 8-Aryloxymethyl- and 8-Arylthiomethyldipyridodiazepinones"
Assay data:41 Active, 40 Activity ≤ 1 µM, 41 Tested
HIV-1 RT Assay from Article 10.1021/jm960837y: "Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase. 6. 2-Indol-3-yl- and 2-azaindol-3-yl-dipyridodiazepinones."
Assay data:7 Active, 1 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 7 Tested
HIV-1 RT Assay from Article 10.1021/jm00088a027: "Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 2. Tricyclic pyridobenzoxazepinones and dibenzoxazepinones."
Assay data:42 Active, 41 Activity ≤ 1 µM, 42 Tested
HIV-1 RT Assay from Article 10.1021/jm00111a045: "Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 1. Tricyclic pyridobenzo- and dipyridodiazepinones."
Assay data:43 Active, 43 Activity ≤ 1 µM, 43 Tested
HIV-1 RT Assay from Article 10.1021/jm00024a011: "Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase. 5. 4-Substituted and 2,4-disubstituted analogs of nevirapine."
Assay data:38 Active, 27 Activity ≤ 1 µM, 38 Tested
HIV-1 RT Assay from Article 10.1021/jm00024a010: "Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. 4. 2-Substituted dipyridodiazepinones as potent inhibitors of both wild-type and cysteine-181 HIV-1 reverse transcriptase enzymes."
Assay data:58 Active, 59 Activity ≤ 1 µM, 60 Tested
Inhibition of wild type recombinant HIV-1 subtype B BH10 p66/p51 reverse transcriptase heterodimer expressed in Escherichia coli BL21 (DE3) assessed as inhibition of dTTP incorporation on poly(rA)-oligo(dT) template primer duplex preincubated with enzyme for 2 mins followed by incubation with poly(A)-oligo(dT) templates for 2 hrs by flourescence assay method
Assay data:2 Active, 2 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of recombinant HIV-1 BH10 reverse transcriptase Y181C mutant using D38/[32P]25PGA as template-primer incubated for 60 mins in absence of DTT followed by dTTP addition and measured after 15 to 30 sec by nucleotide incorporation assay
Assay data:4 Tested
SummaryPubMed Citation
Inhibition of recombinant HIV-1 BH10 reverse transcriptase Y181C mutant using D38/[32P]25PGA as template-primer incubated for 5 mins in presence of DTT followed by dTTP addition and measured after 15 to 30 sec by nucleotide incorporation assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 4 Tested
Inhibition of recombinant HIV-1 BH10 reverse transcriptase using D38/[32P]25PGA as template-primer incubated for 5 mins in presence of DTT followed by dTTP addition and measured after 15 to 30 sec by nucleotide incorporation assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 4 Tested
Inhibition of recombinant HIV-1 BH10 reverse transcriptase p51/p66 expressed in Escherichia coli preincubated for 10 mins followed by D38/25PGA template-primer addition and measured after 10 to 30 secs by denaturing PAGE based single nucleotide incorporation assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 7 Tested
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