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The inhibition of HCMV replication by digitoxin from US Patent US10610539: "Cardiac glycoside analogs and their use in methods for inhibition of viral infection"
Assay data:14 Active, 13 Activity ≤ 1 µM, 14 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
HCMV Polymerase Scintillation Proximity Assay from US Patent US9315499: "Cytomegalovirus inhibitor compounds"
Assay data:3 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
HCMV Polymerase LANCE TR-FRET Assay from US Patent US9315499: "Cytomegalovirus inhibitor compounds"
Assay data:36 Active, 33 Activity ≤ 1 µM, 38 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Nuclear Magnetic Resonance (NMR) Assay from Article 10.1021/bi5003234: "Broad-spectrum allosteric inhibition of herpesvirus proteases."
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of HCMV DNA polymerase incubated for 10 mins in presence of dNTP by fluorescence based assay
Assay data:11 Active, 7 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antiviral activity against HCMV US3-6-EGFP-HCMV-AD169 infected in MRC5 cells assessed as inhibition of viral cytopathic effect incubated for 4 days by fluorescence based HTS assay
Assay data:14 Active, 9 Activity ≤ 1 µM, 16 Tested
Antiviral activity against Human betaherpesvirus 5
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Antiviral activity against Human betaherpesvirus 5 AD 169 infected in HFF cells
Assay data:1 Active, 2 Tested
Antiviral activity against HCMV Davis infected in HELF cells assessed as reduction in viral replication
Assay data:2 Active, 1 Activity ≤ 1 µM, 7 Tested
Antiviral activity against HCMV AD-169 infected in HELF cells assessed as reduction in viral replication
Assay data:2 Active, 7 Tested
Antiviral activity against ganciclovir sensitive HCMV infected in human HELF cells assessed as viral growth inhibition incubated for 8 days
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antiviral activity against ganciclovir resistant HCMV infected in human HELF cells assessed as viral growth inhibition incubated for 8 days
Antiviral activity against HCMV assessed as inhibition of DNA synthesis at 10 uM relative to control
Assay data:1 Tested
SummaryPubMed Citation
Antiviral activity against HCMV
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Antiviral activity against HCMV at 1 uM relative to control
Antiviral activity against HCMV Merlin (RCMV 1111) infected in HFF cells incubated for 96 hrs
Assay data:1 Active, 1 Tested
Antiviral activity against HCMV AD169 infected in HFF cells incubated for 96 hrs
Antiviral activity against HCMV AD-169 infected in HFF cells assessed as reduction in viral replication measured after 14 days
Assay data:1 Active, 1 Activity ≤ 1 µM, 7 Tested
Antiviral activity against HCMV Davis infected in HEL cells assessed as reduction in virus plaque formation
Assay data:3 Active, 1 Activity ≤ 1 µM, 7 Tested
Antiviral activity against HCMV AD-169 infected in HEL cells assessed as reduction in virus plaque formation
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