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Antifertility activity in gerbils assessed as inhibition of spermatid production at 25 mg/kg, po (Rvb = 51.2 %)
Assay data:1 Tested
SummaryPubMed Citation
Cerebral protective activity in anesthetized cerebral ischemia-induced Mongolian gerbil hippocampus assessed as protective values on density of surviving neurons in CA1 subfields of hippocampus at 100 mg/kg, po pretreated for 30 mins followed by bilateral ligation-induced ischemia for 5 mins measured on day 1 post 3 days ischemia induction by hematoxylin and eosin staining based microscopic analysis relative to control
Assay data:23 Tested
Cerebral protective activity in cerebral ischemia-induced Mongolian gerbil assessed as passive avoidance test value at 100 mg/kg, po pretreated for 30 mins followed by bilateral ligation-induced ischemia for 5 mins measured on day 1 post 3 days ischemia induction relative to control
Cmax in Mongolian gerbils plasma
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Antagonist activity at endothelin A receptor in Mongolian gerbil spiral modiolar artery assessed as inhibition of ET-1-induced vasoconstriction at 0.1 to 1 uM treated for 2 mins with ET-1 addition for first min of compound treatment followed by compound washout and again ET-1 addition by video microscopic analysis
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Displacement of [125I]-substance P from gerbil NK1 receptor expressed in HEK293 cell membranes incubated for 30 mins by liquid scintillation counting method
Assay data:53 Active, 11 Activity ≤ 1 nM, 53 Activity ≤ 1 µM, 53 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of [3H]GR205171 from Mongolian gerbil brain NK1 receptor after 60 mins by scintillation counting analysis
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to gerbil NK1 receptor
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Cmax in Mongolian gerbils plasma at 0.5 mg, ip
Neuroprotective activity against BCCO-induced transient cerebral ischemia in mongolian gerbil hippocampal CA1 region assessed as increase in Hsp70 activity at 20 mg/kg, ip administered 20 mins prior to BCCO treatment measured after 24 hrs by immunostaining analysis
Neuroprotective activity against BCCO-induced transient cerebral ischemia in mongolian gerbil hippocampal CA1 region assessed as increase in viable neurons at 100 mg/kg, ip administered immediately after BCCO treatment and measured after 7 days by hematoxylin and eosin staining-based light microscopic analysis relative to control
Neuroprotective activity against BCCO-induced transient cerebral ischemia in mongolian gerbil hippocampal CA1 region assessed as increase in viable neurons at 20 mg/kg, ip administered 20 mins prior to BCCO treatment and measured after 7 days by hematoxylin and eosin staining-based light microscopic analysis relative to control
Neuroprotective activity against BCCO-induced transient cerebral ischemia in mongolian gerbil hippocampal CA1 region assessed as increase in viable neurons at 100 mg/kg, ip administered immediately after BCCO treatment and measured after 7 days by hematoxylin and eosin staining-based light microscopic analysis
Ratio of drug level in brain against plasma in Mongolian gerbil
Assay data:3 Tested
Inhibition of GR73632-induced hind foot tapping in orally dosed mongolian gerbil measured over 5 mins
Summary
Ratio of drug uptake in brain to plasma in Mongolian gerbil at 1 mg/kg, po
Toxicity against jird infected with adult Brugia malayi assessed as behavioural change at 100 mg/kg, sc qd for 5 days measured up to 56 days
Antifilarial activity against Litomosoides carinii infections in the Jird at dose 100 mg/kg administered subcutaneously; two or more animals died prematurely considered to be drug toxicity.
Assay data:4 Tested
Assay data:5 Tested
Inhibition of GR-73632-induced foot tapping in Mongolian gerbil assessed as duration of repetitive hind foot tapping pretreated at 0.1 mg/kg, icv before GR-73632 challenge measured after 4 hrs
Assay data:2 Tested
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