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Dose producing no observable symptom, sign free dose was evaluated
Assay data:4 Tested
SummaryPubMed Citation
pKa Rate constant at 25 degree Centigrade
Assay data:5 Tested
Partition coefficient for 0.1M, pH 7.8 phosphate buffer
pKb Rate constant at 25 degree Centigrade
Neuroprotective activity against Sp-GB-Am-induced AChE inhibition in Swiss Webster mouse assessed as survival at 12.6 mg/kg, ip administered 5 mins post Sp-GB-Am-induction measured after 24 hrs
Assay data:1 Tested
Dissociation constant, pKa of the compound
LD50 expresses the acute toxicity measured after 24 hr in rats
Assay data:7 Tested
Keff is the effective biomolecular rate constant on sarin for reactivation at pH 7.8 at 25 degree Centigrade
Assay data:6 Tested
Keff is the effective biomolecular rate constant on paraxon for reactivation at pH 7.8 at 25 degree Centigrade
Keff is the effective biomolecular rate constant on VX for reactivation at pH 7.8 at 25 degree Centigrade
k2, The intrinsic biomolecular reactivation rate constant on sarin at 25 degree Centigrade
Assay data:2 Tested
k2, The intrinsic biomolecular reactivation rate constant on paraxon at 25 degree Centigrade
K2, The intrinsic biomolecular reactivation rate constant on VX at 25 degree Centigrade
Second-order rate constant for attack on PNPA at 25 degree Centigrade
Binding affinity to paraoxon-inhibited AChE (unknown origin)
Assay data:2 Active, 15 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human AChE using acetylthiocholine as substrate after 4 hrs by robotic spectrophotometric assay
Assay data:4 Active, 1 Activity ≤ 1 µM, 32 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Octanol-phosphate buffer lipophilicity, log P of the compound at pH 7.6 after 24 hrs by shake flask method
Assay data:13 Tested
Dissociation constant, pKa of the compound by Albert and Sergeant/UV-visible spectrophotometry method
Assay data:15 Tested
1-Octanol-sodium phosphate buffer partition coefficient, log P of the compound at pH 7.4 at 25 degC by spectrophotometric analysis
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