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Summary assay for inhibitors of Apaf-1
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Binding affinity to XIAP BIR3-domain (unknown origin)
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at recombinant human XIAP BIR3-domain assessed as recovery of caspase-9 recovery at 1 uM after 1 hr by spectrofluorimetry
Assay data:10 Tested
SummaryPubMed CitationRelated BioAssays by Target
Cytotoxicity against human MCF7 cells assessed as cell viability after by MTT assay
SummaryPubMed Citation
Cytotoxicity against human MDA-MB-231 cells assessed as cell viability after by MTT assay
SAR analysis of small molecule inhibitors of Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay
Assay data:8 Active, 22 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
SAR analysis of small molecule activators of Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay
Assay data:17 Tested
SAR analysis of small molecule Activators of Apaf-1 in a Fluorescent assay
Assay data:5 Active, 98 Tested
SAR analysis of small molecule inhibitors of Apaf-1 in a Fluorescent assay
Assay data:15 Active, 21 Tested
SAR analysis of small molecule Activators of Apaf-1 in a Fluorescent assay - set 2
Assay data:12 Active, 28 Tested
SAR analysis of small molecule Inhibitors of Apaf-1 in a Fluorescent assay - set 2
Assay data:3 Active, 3 Tested
Dose response confirmation of uHTS hits for Apaf-1 activators using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay
Assay data:3 Active, 30 Tested
Dose response confirmation of uHTS hits for Apaf-1 in a Fluorescent assay
Assay data:444 Active, 15 Activity ≤ 1 µM, 476 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Dose Response validation of Activators of Apaf-1 using a Fluorescent Interference Counterscreen assay
Assay data:1 Active, 55 Tested
Dose response confirmation of uHTS hits for Apaf-1 using a LZ-Caspase-9/Caspase-3 Fluorescent Selectivity assay
Assay data:391 Active, 15 Activity ≤ 1 µM, 425 Tested
Dose Response confirmation of uHTS Activators of the Apaf-1 Pathway in Fluorescent format
Assay data:41 Active, 41 Tested
Summary assay for activators of Apaf-1
Induction of apoptosis in human K562 cells assessed as increase in Bax/Bcl-2 ratio at 100 uM measured after 48 hrs by human apoptosis array analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Antiproliferative activity against human A549 cells assessed as inhibition of cell growth
Assay data:14 Active, 2 Activity ≤ 1 µM, 18 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell growth
Assay data:11 Active, 16 Tested
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