Alternative titles; symbols
HGNC Approved Gene Symbol: MOB3C
Cytogenetic location: 1p33 Genomic coordinates (GRCh38): 1:46,607,719-46,616,811 (from NCBI)
MOB3C is a MOB family protein that interacts with the RNase P complex (see 608513), an endonuclease that catalyzes cleavage of the 5-prime leader from precursor tRNAs (Elkholi et al., 2023).
By RT-PCR analysis, Chow et al. (2010) showed that human MOB3C, which they called MOB2C, was expressed in all human tissues examined except kidney and trachea.
Using a proximity-dependent biotin identification approach to define the interactomes of human MOB proteins in HEK293 and HeLa cells, Elkholi et al. (2023) identified an association between MOB3C and 7 of 10 protein subunits of the RNase P complex. They experimentally confirmed that MOB3C specifically interacted with a catalytically active RNase P holoenzyme.
Chow et al. (2010) stated that the MOB3C gene maps to chromosome 1p33.
Chow, A., Hao, Y., Yang, X. Molecular characterization of human homologs of yeast MOB1. Int. J. Cancer 126: 2079-2089, 2010. [PubMed: 19739119] [Full Text: https://doi.org/10.1002/ijc.24878]
Elkholi, I. E., Boulais, J., Thibault, M. P., Phan, H. D., Robert, A., Lai, L. B., Faubert, D., Smith, M. J., Gopalan, V., Cote, J. F. Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex. J. Biol. Chem. 299: 105123, 2023. [PubMed: 37536630] [Full Text: https://doi.org/10.1016/j.jbc.2023.105123]