Entry - *613042 - FAMILY WITH SEQUENCE SIMILARITY 90, MEMBER A3; FAM90A3 - OMIM

 
 
* 613042

FAMILY WITH SEQUENCE SIMILARITY 90, MEMBER A3; FAM90A3


Alternative titles; symbols

FAM90A COPY 2


HGNC Approved Gene Symbol: FAM90A3

Cytogenetic location: 8p23.1     Genomic coordinates (GRCh38): 8:7,264,526-7,267,536 (from NCBI)


TEXT

▼ Description

FAM90A3 belongs to subfamily II of the primate-specific FAM90A gene family, which originated from multiple duplications and rearrangements (Bosch et al., 2007). For background information on the FAM90A gene family, as well as information on the evolution of FAM90A genes, see FAM90A1 (613041).


▼ Cloning and Expression

By analysis of the human genomic sequence (build 36.1), Bosch et al. (2007) identified the FAM90A1 gene on chromosome 12p and 24 additional FAM90A genes and pseudogenes, including FAM90A3, on chromosome 8p. Bosch et al. (2007) referred to FAM90A3 as FAM90A copy 2. The deduced 434-amino acid FAM90A3 protein contains a CCHC-type zinc finger motif, suggesting that it may interact with RNA or DNA. RT-PCR using primers that did not distinguish between individual FAM90A genes suggested that members of FAM90A subfamily II, such as FAM90A3, are ubiquitously expressed.


▼ Gene Structure

Bosch et al. (2007) determined that the FAM90A3 gene contains 5 exons. Exon 1 is noncoding and contains a LINE element, L1MB3, and the sequence 3-prime of the last exon includes a long terminal repeat of the ERV-K family. Like other members of FAM90A subfamily II, FAM90A3 lacks repetitive sequences at its 5-prime end.


▼ Mapping

By analysis of the genomic sequence (build 36.1), Bosch et al. (2007) mapped the FAM90A3 gene to chromosome 8p23.1 (coordinates 7107719 to 7113030). It is the second FAM90A copy, counting distal to proximal, within the FAM90A repeat region and lies within cluster A, which also includes FAM90A15 (613051), FAM90A4P, FAM90A13 (613049), FAM90A5 (613043), and FAM90A20 (613059). FAM90A copies in cluster A are oriented nose to tail on the positive strand.


▼ REFERENCES

  1. Bosch, N., Caceres, M., Cardone, M. F., Carreras, A., Ballana, E., Rocchi, M., Armengol, L., Estivill, X. Characterization and evolution of the novel gene family FAM90A in primates originated by multiple duplication and rearrangement events. Hum. Molec. Genet. 16: 2572-2582, 2007. [PubMed: 17684299, related citations] [Full Text]


Creation Date:
Patricia A. Hartz : 9/29/2009
Edit History:
mgross : 09/30/2009
mgross : 9/30/2009

* 613042

FAMILY WITH SEQUENCE SIMILARITY 90, MEMBER A3; FAM90A3


Alternative titles; symbols

FAM90A COPY 2


HGNC Approved Gene Symbol: FAM90A3

Cytogenetic location: 8p23.1     Genomic coordinates (GRCh38): 8:7,264,526-7,267,536 (from NCBI)


TEXT

Description

FAM90A3 belongs to subfamily II of the primate-specific FAM90A gene family, which originated from multiple duplications and rearrangements (Bosch et al., 2007). For background information on the FAM90A gene family, as well as information on the evolution of FAM90A genes, see FAM90A1 (613041).


Cloning and Expression

By analysis of the human genomic sequence (build 36.1), Bosch et al. (2007) identified the FAM90A1 gene on chromosome 12p and 24 additional FAM90A genes and pseudogenes, including FAM90A3, on chromosome 8p. Bosch et al. (2007) referred to FAM90A3 as FAM90A copy 2. The deduced 434-amino acid FAM90A3 protein contains a CCHC-type zinc finger motif, suggesting that it may interact with RNA or DNA. RT-PCR using primers that did not distinguish between individual FAM90A genes suggested that members of FAM90A subfamily II, such as FAM90A3, are ubiquitously expressed.


Gene Structure

Bosch et al. (2007) determined that the FAM90A3 gene contains 5 exons. Exon 1 is noncoding and contains a LINE element, L1MB3, and the sequence 3-prime of the last exon includes a long terminal repeat of the ERV-K family. Like other members of FAM90A subfamily II, FAM90A3 lacks repetitive sequences at its 5-prime end.


Mapping

By analysis of the genomic sequence (build 36.1), Bosch et al. (2007) mapped the FAM90A3 gene to chromosome 8p23.1 (coordinates 7107719 to 7113030). It is the second FAM90A copy, counting distal to proximal, within the FAM90A repeat region and lies within cluster A, which also includes FAM90A15 (613051), FAM90A4P, FAM90A13 (613049), FAM90A5 (613043), and FAM90A20 (613059). FAM90A copies in cluster A are oriented nose to tail on the positive strand.


REFERENCES

  1. Bosch, N., Caceres, M., Cardone, M. F., Carreras, A., Ballana, E., Rocchi, M., Armengol, L., Estivill, X. Characterization and evolution of the novel gene family FAM90A in primates originated by multiple duplication and rearrangement events. Hum. Molec. Genet. 16: 2572-2582, 2007. [PubMed: 17684299] [Full Text: https://doi.org/10.1093/hmg/ddm209]


Creation Date:
Patricia A. Hartz : 9/29/2009

Edit History:
mgross : 09/30/2009
mgross : 9/30/2009



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: May 29, 2024