Alternative titles; symbols
HGNC Approved Gene Symbol: LINGO2
Cytogenetic location: 9p21.2-p21.1 Genomic coordinates (GRCh38): 9:27,937,617-29,213,601 (from NCBI)
By searching databases for genes similar to LRRN6A (LINGO1; 609791), Carim-Todd et al. (2003) identified LRRN6C. The deduced 606-amino acid protein, which they designated LERN3, has an N-terminal leucine-rich repeat (LRR) domain, followed by 10 typical LRR domains, a C-terminal LRR domain, an IgC2 domain, a transmembrane domain, and a cytoplasmic tail. It shares 60% amino acid identity with LRRN6A.
By genomic sequence analysis, Carim-Todd et al. (2003) mapped the LRRN6C gene to chromosome 9.
Carim-Todd, L., Escarceller, M., Estivill, X., Sumoy, L. LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex. Europ. J. Neurosci. 18: 3167-3182, 2003. [PubMed: 14686891] [Full Text: https://doi.org/10.1111/j.1460-9568.2003.03003.x]