Entry - *604191 - ZINC FINGER PROTEIN 263; ZNF263 - OMIM

 
 
* 604191

ZINC FINGER PROTEIN 263; ZNF263


HGNC Approved Gene Symbol: ZNF263

Cytogenetic location: 16p13.3     Genomic coordinates (GRCh38): 16:3,283,491-3,301,401 (from NCBI)


TEXT

▼ Description

Transcription factors containing a C2H2-type zinc finger motif, such as ZNF263, are involved in the control of cell growth, cell differentiation, or development (Okubo et al., 1995).


▼ Cloning and Expression

By sequencing cDNAs randomly selected from a cDNA library generated from granulocytoid cells that were derived from the human promyelocytic leukemia cell line 60 (HL60), Okubo et al. (1995) identified partial cDNAs representing several novel genes. Using 1 of these cDNAs, Yokoyama et al. (1997) isolated a full-length cDNA encoding ZNF263, which they named FPM315. The deduced 683-amino acid protein contains 9 C-terminal C2H2-type zinc finger domains, some of which are connected by H/C links; a KRAB A box, which has been shown in other ZNFs to act as a transcriptional repressor domain; and an N-terminal leucine-rich region (LeR) that is also rich in glutamic acids, is highly conserved in a subset of ZNFs, and is predicted to contain 2 alpha helices. Northern blot analysis detected 2 major transcripts of approximately 3.4 and 3.8 kb. ZNF263 was expressed in all human fetal and adult tissues examined.


▼ Mapping

Gross (2014) mapped the ZNF263 gene to chromosome 16p13.3 based on an alignment of the ZNF263 sequence (GenBank BC008805) with the genomic sequence (GRCh37).

▼ REFERENCES

  1. Gross, M. B. Personal Communication. Baltimore, Md. 6/25/2014.

  2. Okubo, K., Itoh, K., Fukushima, A., Yoshii, J., Matsubara, K. Monitoring cell physiology by expression profiles and discovering cell type-specific genes by compiled expression profiles. Genomics 30: 178-186, 1995. [PubMed: 8586417, related citations] [Full Text]

  3. Yokoyama, M., Nakamura, M., Okubo, K., Matsubara, K., Nishi, Y., Matsumoto, T., Fukushima, A. Isolation of a cDNA encoding a widely expressed novel zinc finger protein with the LeR and KRAB-A domains. Biochim. Biophys. Acta 1353: 13-17, 1997. [PubMed: 9256059, related citations] [Full Text]


Contributors:
Matthew B. Gross - updated : 06/25/2014
Creation Date:
Patti M. Sherman : 9/28/1999
Edit History:
mgross : 06/25/2014
mgross : 9/29/1999
psherman : 9/28/1999

* 604191

ZINC FINGER PROTEIN 263; ZNF263


HGNC Approved Gene Symbol: ZNF263

Cytogenetic location: 16p13.3     Genomic coordinates (GRCh38): 16:3,283,491-3,301,401 (from NCBI)


TEXT

Description

Transcription factors containing a C2H2-type zinc finger motif, such as ZNF263, are involved in the control of cell growth, cell differentiation, or development (Okubo et al., 1995).


Cloning and Expression

By sequencing cDNAs randomly selected from a cDNA library generated from granulocytoid cells that were derived from the human promyelocytic leukemia cell line 60 (HL60), Okubo et al. (1995) identified partial cDNAs representing several novel genes. Using 1 of these cDNAs, Yokoyama et al. (1997) isolated a full-length cDNA encoding ZNF263, which they named FPM315. The deduced 683-amino acid protein contains 9 C-terminal C2H2-type zinc finger domains, some of which are connected by H/C links; a KRAB A box, which has been shown in other ZNFs to act as a transcriptional repressor domain; and an N-terminal leucine-rich region (LeR) that is also rich in glutamic acids, is highly conserved in a subset of ZNFs, and is predicted to contain 2 alpha helices. Northern blot analysis detected 2 major transcripts of approximately 3.4 and 3.8 kb. ZNF263 was expressed in all human fetal and adult tissues examined.


Mapping

Gross (2014) mapped the ZNF263 gene to chromosome 16p13.3 based on an alignment of the ZNF263 sequence (GenBank BC008805) with the genomic sequence (GRCh37).

REFERENCES

  1. Gross, M. B. Personal Communication. Baltimore, Md. 6/25/2014.

  2. Okubo, K., Itoh, K., Fukushima, A., Yoshii, J., Matsubara, K. Monitoring cell physiology by expression profiles and discovering cell type-specific genes by compiled expression profiles. Genomics 30: 178-186, 1995. [PubMed: 8586417] [Full Text: https://doi.org/10.1006/geno.1995.9887]

  3. Yokoyama, M., Nakamura, M., Okubo, K., Matsubara, K., Nishi, Y., Matsumoto, T., Fukushima, A. Isolation of a cDNA encoding a widely expressed novel zinc finger protein with the LeR and KRAB-A domains. Biochim. Biophys. Acta 1353: 13-17, 1997. [PubMed: 9256059] [Full Text: https://doi.org/10.1016/s0167-4781(97)00074-2]


Contributors:
Matthew B. Gross - updated : 06/25/2014

Creation Date:
Patti M. Sherman : 9/28/1999

Edit History:
mgross : 06/25/2014
mgross : 9/29/1999
psherman : 9/28/1999



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OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.

NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
OMIM® and Online Mendelian Inheritance in Man® are registered trademarks of the Johns Hopkins University.
Copyright® 1966-2024 Johns Hopkins University.
Printed: June 7, 2024