histidine--tRNA ligase, cytoplasmic isoform 5 [Homo sapiens]

Run BLAST
Find regions of similarity between this sequence and other sequences using BLAST.
Identify Conserved Domains
View conserved domains detected in this protein sequence using CD-search.
Highlight Sequence Features
Opens the Highlight Feature Bar and highlights feature annotations from the FEATURES table of the record. The Highlight Feature Bar can be used to navigate to and highlight other features and provides links to display the highlighted region separately. Links in the FEATURES table will also highlight the corresponding region of the sequence. More...
Find in this Sequence
Finds sub-sequences or patterns in the sequence and highlights the matching regions. The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences. More...
Show in Genome Data Viewer
Opens the Genome Data Viewer, NCBI's genome browser, at the genomic location at which this sequence is annotated. View this sequence in the context of other features annotated at the same location and browse to other genome regions.

Bi-allelic mutations in HARS1 severely impair histidyl-tRNA synthetase expression and enzymatic activity causing a novel multisystem ataxic syndrome. [Hum Mutat. 2020]
Bi-allelic mutations in HARS1 severely impair histidyl-tRNA synthetase expression and enzymatic activity causing a novel multisystem ataxic syndrome.
Galatolo D, Kuo ME, Mullen P, Meyer-Schuman R, Doccini S, Battini R, Lieto M, Tessa A, Filla A, Francklyn C, et al. Hum Mutat. 2020 Jul; 41(7):1232-1237. Epub 2020 Apr 29.
Serum-circulating His-tRNA synthetase inhibits organ-targeted immune responses. [Cell Mol Immunol. 2021]
Serum-circulating His-tRNA synthetase inhibits organ-targeted immune responses.
Adams RA, Fernandes-Cerqueira C, Notarnicola A, Mertsching E, Xu Z, Lo WS, Ogilvie K, Chiang KP, Ampudia J, Rosengren S, et al. Cell Mol Immunol. 2021 Jun; 18(6):1463-1475. Epub 2019 Dec 4.
The Usher Syndrome Type IIIB Histidyl-tRNA Synthetase Mutation Confers Temperature Sensitivity. [Biochemistry. 2017]
The Usher Syndrome Type IIIB Histidyl-tRNA Synthetase Mutation Confers Temperature Sensitivity.
Abbott JA, Guth E, Kim C, Regan C, Siu VM, Rupar CA, Demeler B, Francklyn CS, Robey-Bond SM. Biochemistry. 2017 Jul 18; 56(28):3619-3631. Epub 2017 Jul 7.

RefSeq genomic sequence
See the genomic reference sequence for the HARS1 gene (NG_032158.1).
RefSeq mRNA
See reference mRNA sequence for the HARS1 gene (NM_001289092.2).
RefSeq protein isoforms
See 7 reference sequence protein isoforms for the HARS1 gene.

BioProject
Proteins related to BioProjects
Nucleotide
Nucleotide sequence from coding region
PubMed
PubMed articles cited by protein sequence record
Taxonomy
Taxonomy sequences associated with protein record
BioSystems
BioSystems
CCDS
Link to Consensus CDS
CDD Search Results
Display conserved domains within a protein
Conserved Domains (Concise)
Link to a concise list of conserved domains in a protein
Conserved Domains (Full)
Link to conserved domains within a protein
Domain Relatives
Display proteins with similar conserved domain architecture
Encoding mRNA
Link from protein to encoding mRNA
Full text in PMC
Free full text articles in PMC
Gene
Link to related Genes
Genome
Genome record encoding protein sequence
Identical Structures
3D structures for identical protein sequences
OMIM
OMIM records associated with protein sequence
PubMed (RefSeq)
Link to RefSeq PubMed articles
PubMed (Weighted)
Links to pubmed
SNP
Related SNPs

Ensembl [Ensembl]
Ensembl
GlyGen glycoinformatics resource [GlyGen glycoinformatics resou...]
GlyGen glycoinformatics resource
reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome

histidine--tRNA ligase, cytoplasmic isoform 5 [Homo sapiens]
histidine--tRNA ligase, cytoplasmic isoform 5 [Homo sapiens]
gi|574278766|ref|NP_001276021.1|

Protein
Eyelids
Eyelids
Each of the upper and lower folds of SKIN which cover the EYE when closed.<br/>

MeSH
Product Line Management
Product Line Management
Management control systems for structuring health care delivery strategies around case types, as in DRGs, or specific clinical services.<br/>Year introduced: 1991(1988)

MeSH
Genetic Phenomena
Genetic Phenomena
The biological processes, properties, and objects that are involved in maintaining, expressing, and transmitting from one organism to another, genetically encoded traits....<br/>Year introduced: 2009

MeSH

Your browsing activity is empty.

Activity recording is turned off.

Protein