Homo sapiens twinkle mtDNA helicase (TWNK), transcript variant 1, mRNA

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Cancer-associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7. [Mol Oncol. 2024]
Cancer-associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7.
Baxter JS, Brough R, Krastev DB, Song F, Sridhar S, Gulati A, Alexander J, Roumeliotis TI, Kozik Z, Choudhary JS, et al. Mol Oncol. 2024 Feb; 18(2):369-385. Epub 2023 Oct 22.
The N-terminal domain of human mitochondrial helicase Twinkle has DNA-binding activity crucial for supporting processive DNA synthesis by polymerase γ. [J Biol Chem. 2023]
The N-terminal domain of human mitochondrial helicase Twinkle has DNA-binding activity crucial for supporting processive DNA synthesis by polymerase γ.
Johnson LC, Singh A, Patel SS. J Biol Chem. 2023 Jan; 299(1):102797. Epub 2022 Dec 14.
Structural insight and characterization of human Twinkle helicase in mitochondrial disease. [Proc Natl Acad Sci U S A. 2022]
Structural insight and characterization of human Twinkle helicase in mitochondrial disease.
Riccio AA, Bouvette J, Perera L, Longley MJ, Krahn JM, Williams JG, Dutcher R, Borgnia MJ, Copeland WC. Proc Natl Acad Sci U S A. 2022 Aug 9; 119(32):e2207459119. Epub 2022 Aug 1.

RefSeq alternative splicing
See 5 reference mRNA sequence splice variants for the TWNK gene.
RefSeq protein product
See the reference protein sequence for twinkle mtDNA helicase isoform A (NP_068602.2).

Protein
Protein sequence from Nucleotide coding region
PubMed
PubMed articles cited by Nucleotide sequence record
Taxonomy
Taxonomy sequences associated with Nucleotide record
Annotated Genomic
Genomic sequence records that have the current RNA records as annotated features marking the exons of genes.
BioSystems
BioSystems
CCDS
Link to Consensus CDS
Components (Core)
Links to Core components
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Free full text articles in PMC
Functional Class
Functional class of the sequence domain architecture
Gene
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OMIM
OMIM records associated with Nucleotide sequence
Probe
Related Probe entry
PubMed (RefSeq)
Link to RefSeq PubMed articles
PubMed (Weighted)
Links to pubmed

Ensembl [Ensembl]
Ensembl
GenScript latest version of gene cDNA ORF Clone [GenScript latest version of g...]
GenScript latest version of gene cDNA ORF Clone
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UCSC Genome Browser [UCSC Genome Browser]
UCSC Genome Browser

LOC100788761 [Glycine max]
LOC100788761 [Glycine max]
Gene ID:100788761

Gene
LOC107459705 [Arachis duranensis]
LOC107459705 [Arachis duranensis]
Gene ID:107459705

Gene

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Nucleotide