Memory deficits in a juvenile rat model of type 1 diabetes are due to excess 11β-HSD1 activity, which is upregulated by high glucose concentrations rather than insulin deficiency.
Brossaud J, Bosch-Bouju C, Marissal-Arvy N, Campas-Lebecque MN, Helbling JC, Webster SP, Walker BR, Fioramonti X, Ferreira G, Barat P, et al. Diabetologia. 2023 Sep; 66(9):1735-1747. Epub 2023 Jun 10.