Mus musculus checkpoint kinase 1 (Chek1), transcript variant 1, mRNA

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Hydrogen sulfide ameliorates lipopolysaccharide-induced anxiety-like behavior by inhibiting checkpoint kinase 1 activation in the hippocampus of mice. [Exp Neurol. 2024]
Hydrogen sulfide ameliorates lipopolysaccharide-induced anxiety-like behavior by inhibiting checkpoint kinase 1 activation in the hippocampus of mice.
Shentu Y, Chen M, Wang H, Du X, Zhang W, Xie G, Zhou S, Ding L, Zhu Y, Zhu M, et al. Exp Neurol. 2024 Jan; 371:114586. Epub 2023 Oct 26.
SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice. [Arch Toxicol. 2023]
SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice.
Chen JW, Shan TK, Wei TW, Jiang QQ, Du C, Gu LF, Yang TT, Zhou LH, Wang SB, Bao YL, et al. Arch Toxicol. 2023 Dec; 97(12):3209-3226. Epub 2023 Oct 5.
Inhibition of RRM2 radiosensitizes glioblastoma and uncovers synthetic lethality in combination with targeting CHK1. [Cancer Lett. 2023]
Inhibition of RRM2 radiosensitizes glioblastoma and uncovers synthetic lethality in combination with targeting CHK1.
Corrales-Guerrero S, Cui T, Castro-Aceituno V, Yang L, Nair S, Feng H, Venere M, Yoon S, DeWees T, Shen C, et al. Cancer Lett. 2023 Aug 28; 570:216308. Epub 2023 Jul 22.

RefSeq alternative splicing
See 5 reference mRNA sequence splice variants for the Chek1 gene.
RefSeq protein product
See the reference protein sequence for serine/threonine-protein kinase Chk1 isoform 1 (NP_031717.2).

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Ensembl [Ensembl]
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checkpoint kinase 1 [Guide to Pharmacology]
checkpoint kinase 1
Guide to Pharmacology
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GenScript latest version of gene cDNA ORF Clone
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Nucleotide