Homo sapiens hyperpolarization activated cyclic nucleotide gated potas - Nucleotide

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A gain-of-function HCN4 mutant in the HCN domain is responsible for inappropriate sinus tachycardia in a Spanish family. [Proc Natl Acad Sci U S A. 2023]
A gain-of-function HCN4 mutant in the HCN domain is responsible for inappropriate sinus tachycardia in a Spanish family.
Cámara-Checa A, Perin F, Rubio-Alarcón M, Dago M, Crespo-García T, Rapún J, Marín M, Cebrián J, Gómez R, Bermúdez-Jiménez F, et al. Proc Natl Acad Sci U S A. 2023 Dec 5; 120(49):e2305135120. Epub 2023 Nov 30.
Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia. [iScience. 2023]
Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.
Hsu YH, Pintacuda G, Liu R, Nacu E, Kim A, Tsafou K, Petrossian N, Crotty W, Suh JM, Riseman J, et al. iScience. 2023 May 19; 26(5):106701. Epub 2023 Apr 18.
Channel HCN4 mutation R666Q associated with sporadic arrhythmia decreases channel electrophysiological function and increases protein degradation. [J Biol Chem. 2022]
Channel HCN4 mutation R666Q associated with sporadic arrhythmia decreases channel electrophysiological function and increases protein degradation.
Wang H, Wu T, Huang Z, Huang J, Geng Z, Cui B, Yan Y, Zhang Y, Wang Y. J Biol Chem. 2022 Nov; 298(11):102599. Epub 2022 Oct 14.

RefSeq alternative splicing
See 3 reference mRNA sequence splice variants for the HCN4 gene.
RefSeq protein product
See the reference protein sequence for potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (NP_005468.1).

Protein
Protein sequence from Nucleotide coding region
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Ensembl [Ensembl]
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HCN4 [Guide to Pharmacology]
HCN4
Guide to Pharmacology
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dihydroorotate dehydrogenase family protein [Naegleria gruberi]
dihydroorotate dehydrogenase family protein [Naegleria gruberi]
gi|284094242|gb|EFC47877.1||gnl|WGS |NAEGRDRAFT_78714

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Nucleotide