Homo sapiens ADAM metallopeptidase domain 17 (ADAM17), transcript vari - Nucleotide

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Ectodomain shedding of PLA2R1 is mediated by the metalloproteases ADAM10 and ADAM17. [J Biol Chem. 2024]
Ectodomain shedding of PLA2R1 is mediated by the metalloproteases ADAM10 and ADAM17.
Dolla G, Nicolas S, Dos Santos LR, Bourgeois A, Pardossi-Piquard R, Bihl F, Zaghrini C, Justino J, Payré C, Mansuelle P, et al. J Biol Chem. 2024 Jul; 300(7):107480. Epub 2024 Jun 17.
Downregulation of the metalloproteinases ADAM10 or ADAM17 promotes osteoclast differentiation. [Cell Commun Signal. 2024]
Downregulation of the metalloproteinases ADAM10 or ADAM17 promotes osteoclast differentiation.
Babendreyer A, Kieselhorst J, Rinkens C, Lyashenko AM, Düsterhöft S, Jahr H, Craveiro RB, Wolf M, Ludwig A. Cell Commun Signal. 2024 Jun 11; 22(1):322. Epub 2024 Jun 11.
Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals. [Mol Cell. 2024]
Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals.
Lu F, Zhao H, Dai Y, Wang Y, Lee CH, Freeman M. Mol Cell. 2024 Jun 6; 84(11):2152-2165.e5. Epub 2024 May 22.

RefSeq alternative splicing
See 8 reference mRNA sequence splice variants for the ADAM17 gene.
RefSeq protein product
See the reference protein sequence for disintegrin and metalloproteinase domain-containing protein 17 isoform 1 preproprotein (NP_003174.3).

Protein
Protein sequence from Nucleotide coding region
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Ensembl [Ensembl]
Ensembl
ADAM17 [Guide to Pharmacology]
ADAM17
Guide to Pharmacology
GenScript latest version of gene cDNA ORF Clone [GenScript latest version of g...]
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Structure Links for Protein (Select 2462592234) (18)
Structure
Assembly links for BioSample (Select 16425977) (1)
Assembly
Gene Links for GEO Profiles (Select 22837374) (1)
Gene
SSR2 signal sequence receptor subunit 2 [Homo sapiens]
SSR2 signal sequence receptor subunit 2 [Homo sapiens]
Gene ID:6746

Gene
Related DataSets for GEO Profiles (Select 22840287) (1)
GEO DataSets

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Nucleotide