Homo sapiens unc-13 homolog A (UNC13A), transcript variant 4, mRNA

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Cryptic splicing of stathmin-2 and UNC13A mRNAs is a pathological hallmark of TDP-43-associated Alzheimer's disease. [Acta Neuropathol. 2024]
Cryptic splicing of stathmin-2 and UNC13A mRNAs is a pathological hallmark of TDP-43-associated Alzheimer's disease.
Agra Almeida Quadros AR, Li Z, Wang X, Ndayambaje IS, Aryal S, Ramesh N, Nolan M, Jayakumar R, Han Y, Stillman H, et al. Acta Neuropathol. 2024 Jan 4; 147(1):9. Epub 2024 Jan 4.
Interaction of the C9orf72-Amyotrophic Lateral Sclerosis-Related Proline-Arginine Dipeptide Repeat Protein with the RNA-Binding Protein NOVA1 Causes Decreased Expression of UNC13A Due to Enhanced Inclusion of Cryptic Exons, Which Is Reversed by Betulin Treatment. [Cells. 2023]
Interaction of the C9orf72-Amyotrophic Lateral Sclerosis-Related Proline-Arginine Dipeptide Repeat Protein with the RNA-Binding Protein NOVA1 Causes Decreased Expression of UNC13A Due to Enhanced Inclusion of Cryptic Exons, Which Is Reversed by Betulin Treatment.
Fu RH, Chen HJ, Hong SY. Cells. 2023 Oct 18; 12(20). Epub 2023 Oct 18.
TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A. [Nature. 2022]
TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A.
Brown AL, Wilkins OG, Keuss MJ, Hill SE, Zanovello M, Lee WC, Bampton A, Lee FCY, Masino L, Qi YA, et al. Nature. 2022 Mar; 603(7899):131-137. Epub 2022 Feb 23.

RefSeq alternative splicing
See 10 reference mRNA sequence splice variants for the UNC13A gene.
RefSeq protein product
See the reference protein sequence for protein unc-13 homolog A isoform 4 (NP_001373952.1).

Protein
Protein sequence from Nucleotide coding region
PubMed
PubMed articles cited by Nucleotide sequence record
Taxonomy
Taxonomy sequences associated with Nucleotide record
Annotated Genomic
Genomic sequence records that have the current RNA records as annotated features marking the exons of genes.
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BioSystems
CCDS
Link to Consensus CDS
Components (Core)
Links to Core components
Gene
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OMIM
OMIM records associated with Nucleotide sequence
PubMed (RefSeq)
Link to RefSeq PubMed articles
PubMed (Weighted)
Links to pubmed

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