Homo sapiens protein tyrosine phosphatase non-receptor type 11 (PTPN11 - Nucleotide

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SHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54 to amend androgen receptor homeostasis. [Nat Commun. 2024]
SHP2 as a primordial epigenetic enzyme expunges histone H3 pTyr-54 to amend androgen receptor homeostasis.
Chouhan S, Sridaran D, Weimholt C, Luo J, Li T, Hodgson MC, Santos LN, Le Sommer S, Fang B, Koomen JM, et al. Nat Commun. 2024 Jul 4; 15(1):5629. Epub 2024 Jul 4.
MEK-SHP2 inhibition prevents tibial pseudarthrosis caused by NF1 loss in Schwann cells and skeletal stem/progenitor cells. [Sci Transl Med. 2024]
MEK-SHP2 inhibition prevents tibial pseudarthrosis caused by NF1 loss in Schwann cells and skeletal stem/progenitor cells.
Perrin S, Protic S, Bretegnier V, Laurendeau I, de Lageneste OD, Panara N, Ruckebusch O, Luka M, Masson C, Maillard T, et al. Sci Transl Med. 2024 Jun 26; 16(753):eadj1597. Epub 2024 Jun 26.
SHP2 regulates GluA2 tyrosine phosphorylation required for AMPA receptor endocytosis and mGluR-LTD. [Proc Natl Acad Sci U S A. 2024]
SHP2 regulates GluA2 tyrosine phosphorylation required for AMPA receptor endocytosis and mGluR-LTD.
Lee S, Kim J, Ryu HH, Jang H, Lee D, Lee S, Song JM, Lee YS, Suh YH. Proc Natl Acad Sci U S A. 2024 Apr 30; 121(18):e2316819121. Epub 2024 Apr 24.

RefSeq alternative splicing
See 6 reference mRNA sequence splice variants for the PTPN11 gene.
RefSeq protein product
See the reference protein sequence for tyrosine-protein phosphatase non-receptor type 11 isoform 4 (NP_001361554.1).

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Protein sequence from Nucleotide coding region
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Nucleotide