Homo sapiens HECT and RLD domain containing E3 ubiquitin protein ligas - Nucleotide

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HERC3 facilitates ERAD of select membrane proteins by recognizing membrane-spanning domains. [J Cell Biol. 2024]
HERC3 facilitates ERAD of select membrane proteins by recognizing membrane-spanning domains.
Kamada Y, Ohnishi Y, Nakashima C, Fujii A, Terakawa M, Hamano I, Nakayamada U, Katoh S, Hirata N, Tateishi H, et al. J Cell Biol. 2024 Jul 1; 223(7). Epub 2024 May 9.
HERC3 promotes YAP/TAZ stability and tumorigenesis independently of its ubiquitin ligase activity. [EMBO J. 2023]
HERC3 promotes YAP/TAZ stability and tumorigenesis independently of its ubiquitin ligase activity.
Yuan B, Liu J, Shi A, Cao J, Yu Y, Zhu Y, Zhang C, Qiu Y, Luo H, Shi J, et al. EMBO J. 2023 Feb 15; 42(4):e111549. Epub 2023 Jan 4.
A Novel ERK2 Degrader Z734 Induces Apoptosis of MCF-7 Cells via the HERC3/p53 Signaling Pathway. [Molecules. 2022]
A Novel ERK2 Degrader Z734 Induces Apoptosis of MCF-7 Cells via the HERC3/p53 Signaling Pathway.
Xu S, Xiong Y, Yao R, Tian R, Meng Z, Zaky MY, Fu B, Guo D, Wang L, Lin F, et al. Molecules. 2022 Jul 6; 27(14). Epub 2022 Jul 6.

RefSeq alternative splicing
See 10 reference mRNA sequence splice variants for the HERC3 gene.
RefSeq protein product
See the reference protein sequence for probable E3 ubiquitin-protein ligase HERC3 isoform 2 (NP_001258531.1).

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Protein sequence from Nucleotide coding region
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Nucleotide