Homo sapiens leptin (LEP), mRNA

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Opens the Genome Data Viewer, NCBI's genome browser, at the genomic location at which this sequence is annotated. View this sequence in the context of other features annotated at the same location and browse to other genome regions.

A negative feedback loop between TET2 and leptin in adipocyte regulates body weight. [Nat Commun. 2024]
A negative feedback loop between TET2 and leptin in adipocyte regulates body weight.
Zeng Q, Song J, Sun X, Wang D, Liao X, Ding Y, Hu W, Jiao Y, Mai W, Aini W, et al. Nat Commun. 2024 Apr 1; 15(1):2825. Epub 2024 Apr 1.
Unexpected identification of obesity-associated mutations in LEP and MC4R genes in patients with anorexia nervosa. [Sci Rep. 2024]
Unexpected identification of obesity-associated mutations in LEP and MC4R genes in patients with anorexia nervosa.
Rajcsanyi LS, Zheng Y, Herpertz-Dahlmann B, Seitz J, de Zwaan M, Herzog W, Ehrlich S, Zipfel S, Giel K, Egberts K, et al. Sci Rep. 2024 Mar 25; 14(1):7067. Epub 2024 Mar 25.
Novel mechanisms involved in leptin sensitization in obesity. [Biochem Pharmacol. 2024]
Novel mechanisms involved in leptin sensitization in obesity.
Pena-Leon V, Perez-Lois R, Villalon M, Prida E, Muñoz-Moreno D, Fernø J, Quiñones M, Al-Massadi O, Seoane LM. Biochem Pharmacol. 2024 May; 223:116129. Epub 2024 Mar 13.

RefSeq alternative splicing
See 3 reference mRNA sequence splice variants for the LEP gene.
RefSeq protein product
See the reference protein sequence for leptin precursor (NP_000221.1).

Protein
Protein sequence from Nucleotide coding region
PubMed
PubMed articles cited by Nucleotide sequence record
Taxonomy
Taxonomy sequences associated with Nucleotide record
Annotated Genomic
Genomic sequence records that have the current RNA records as annotated features marking the exons of genes.
BioSystems
BioSystems
CCDS
Link to Consensus CDS
Components (Core)
Links to Core components
Full text in PMC
Free full text articles in PMC
Functional Class
Functional class of the sequence domain architecture
Gene
Link to related Genes
OMIM
OMIM records associated with Nucleotide sequence
Probe
Related Probe entry
PubMed (RefSeq)
Link to RefSeq PubMed articles
PubMed (Weighted)
Links to pubmed

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