Homo sapiens 3-hydroxy-3-methylglutaryl-CoA lyase (HMGCL), transcript - Nucleotide

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Metabolic modulation of histone acetylation mediated by HMGCL activates the FOXM1/β-catenin pathway in glioblastoma. [Neuro Oncol. 2024]
Metabolic modulation of histone acetylation mediated by HMGCL activates the FOXM1/β-catenin pathway in glioblastoma.
Sun Y, Mu G, Zhang X, Wu Y, Wang S, Wang X, Xue Z, Wang C, Liu J, Li W, et al. Neuro Oncol. 2024 Apr 5; 26(4):653-669.
Phosphorylation by IKKβ Promotes the Degradation of HMGCL via NEDD4 in Lung Cancer. [Int J Biol Sci. 2023]
Phosphorylation by IKKβ Promotes the Degradation of HMGCL via NEDD4 in Lung Cancer.
Zhong C, Xiong G, Yang H, Du X, Du J, Yao F, Fang W, Deng Y. Int J Biol Sci. 2023; 19(4):1110-1122. Epub 2023 Feb 5.
HMGCL-induced β-hydroxybutyrate production attenuates hepatocellular carcinoma via DPP4-mediated ferroptosis susceptibility. [Hepatol Int. 2023]
HMGCL-induced β-hydroxybutyrate production attenuates hepatocellular carcinoma via DPP4-mediated ferroptosis susceptibility.
Cui X, Yun X, Sun M, Li R, Lyu X, Lao Y, Qin X, Yu W. Hepatol Int. 2023 Apr; 17(2):377-392. Epub 2022 Dec 12.

RefSeq alternative splicing
See the other reference mRNA sequence splice variant for the HMGCL gene (NM_001166059.2).
RefSeq protein product
See the reference protein sequence for hydroxymethylglutaryl-CoA lyase, mitochondrial isoform 1 precursor (NP_000182.2).

Protein
Protein sequence from Nucleotide coding region
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Functional Class
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OMIM
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PubMed (RefSeq)
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Homo sapiens 3-hydroxy-3-methylglutaryl-CoA lyase (HMGCL), transcript variant 1,...
Homo sapiens 3-hydroxy-3-methylglutaryl-CoA lyase (HMGCL), transcript variant 1, mRNA; nuclear gene for mitochondrial product
gi|1519315368|ref|NM_000191.3|

Nucleotide

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Nucleotide