Homo sapiens spastin (SPAST), RefSeqGene (LRG_714) on chromosome 2

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A novel truncated variant in SPAST results in spastin accumulation and defects in microtubule dynamics. [BMC Med Genomics. 2023]
A novel truncated variant in SPAST results in spastin accumulation and defects in microtubule dynamics.
Wang J, Wu Y, Dong H, Ji Y, Zhang L, Liu Y, Liu Y, Gao X, Jia Y, Wang X. BMC Med Genomics. 2023 Dec 8; 16(1):321. Epub 2023 Dec 8.
Identification of c.1495C > T mutation in SPAST gene in a family of Han Chinese with hereditary spastic paraplegia. [Neurosci Lett. 2023]
Identification of c.1495C > T mutation in SPAST gene in a family of Han Chinese with hereditary spastic paraplegia.
Chen X, Li X, Tan Y, Yang D, Lu L, Deng Y, Xu R. Neurosci Lett. 2023 Aug 24; 812:137399. Epub 2023 Jul 19.
Spastin is required for human immunodeficiency virus-1 efficient replication through cooperation with the endosomal sorting complex required for transport (ESCRT) protein. [Virol Sin. 2023]
Spastin is required for human immunodeficiency virus-1 efficient replication through cooperation with the endosomal sorting complex required for transport (ESCRT) protein.
Shen W, Liu C, Hu Y, Ding Q, Feng J, Liu Z, Kong X. Virol Sin. 2023 Jun; 38(3):448-458. Epub 2023 May 11.

RefSeq alternative splicing
See 5 reference mRNA sequence splice variants for the SPAST gene.

Protein
Protein sequence from Nucleotide coding region
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Nucleotide