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Neutrophils : acute responders in chronic inflammatory diseases
- Author(s):
- Kaplan, Mariana, speaker
- National Institutes of Health (US) Immunology Interest Group, sponsoring body
- Title(s):
- Neutrophils : acute responders in chronic inflammatory diseases / Mariana J. Kaplan.
- Uniform Title:
- Neutrophils (Kaplan)
- Series:
- IIG seminar
- Country of Publication:
- United States
- Publisher:
- [Bethesda, Md.] : [National Institutes of Health], [2024]
- Description:
- 1 online resource (1 streaming video file (1 hr., 6 min.)) : color, sound.
-
Language:
- English
- Electronic Links:
- https://videocast.nih.gov/watch=54000
- Summary:
- (CIT): Dr. Kaplan's research has focused on identifying mechanisms of immune dysregulation, organ damage, and premature vascular disease in systemic autoimmunity. More specifically, she investigates how innate immunity (in particular, type I interferons and myeloid cells) promote autoimmune responses and end-organ damage in systemic lupus erythematosus, rheumatoid arthritis, and other systemic autoimmune diseases. Recently, her research has focused on identifying abnormalities of neutrophil subsets, aberrant myeloid immunometabolism and the role of neutrophil extracellular traps (NETs) in systemic autoimmune disorders and chronic inflammatory disease, both of which may contribute to the development of autoimmune responses and end-organ damage. Dr. Kaplan also has an interest in identifying novel therapeutic targets that may prevent premature vascular damage in systemic autoimmunity, as well as the role of environmental triggers in the induction of autoimmunity. Moreover, she has led clinical trials to identify mechanisms that reduce blood vessel dysfunction and mitigate organ damage in autoimmune and chronic inflammatory disorders.
- MeSH:
- Autoimmune Diseases/immunology
Autoimmune Diseases/metabolism*
Autoimmunity
Lupus Erythematosus, Systemic/immunology*
Lupus Erythematosus, Systemic/metabolism
Neutrophils/immunology
- Publication Type(s):
- Lecture
Webcast
- Notes:
- Recorded January 10, 2024.
Closed-captioned.
- Terms of Use:
- Access restricted to HHS only.
- Other ID:
- (DNLM)33705
(OCoLC)1457225315
- NLM ID:
- 9918768587106676 [Remote electronic resource, Videorecording]