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Controlling the message : viral manipulation of the gene expression landscape
- Author(s):
- Glaunsinger, Britt, speaker
- National Institutes of Health (US), issuing body
- Title(s):
- Controlling the message : viral manipulation of the gene expression landscape / Britt Glaunsinger.
- Series:
- NIH Wednesday afternoon lecture
- Country of Publication:
- United States
- Publisher:
- [Bethesda, Md.] : [National Institutes of Health], [2023]
- Description:
- 1 online resource (1 streaming video file (1 hr., 2 min.)) : color, sound.
-
Language:
- English
- Electronic Links:
- https://videocast.nih.gov/watch=45970
- Summary:
- (CIT): This is the Annual WALS George Khoury Lecture. Speaker Britt Glaunsinger, Ph.D., is a professor in the Department of Molecular & Cell Biology and in Plant and Microbial Biology at University of California, Berkeley. Lecture summary: Oncogenic herpesviruses such as Kaposi"s sarcoma-associated herpesvirus restrict cellular gene expression to dampen immune responses, while simultaneously stealing the cell"s machinery to express viral genes. This restriction initiates through accelerated mRNA decay in the cytoplasm, which subsequently induces broad repression of cellular mRNA synthesis both via relocalization of RNA binding proteins and turnover of RNA polymerase subunits. Herpesviruses, which are among the most successful human pathogens, have evolved to escape this repression and maintain robust viral transcription. Late in infection, the virus assembles a unique virus-host hybrid transcription complex that connects viral gene expression to viral DNA replication and genome packaging. By studying how herpesviruses interface with these gene expression pathways, we hope to uncover conserved stress responses and new connections between seemingly distal components of the gene expression cascade.For more information go to <a href="https://oir.nih.gov/wals">https://oir.nih.gov/wals.
- MeSH:
- Gene Expression Regulation, Viral*
- Publication Type(s):
- Lecture
Webcast
- Notes:
- Recorded March 29, 2023.
Closed-captioned.
- Other ID:
- (DNLM)33069
(OCoLC)1390179799
- NLM ID:
- 9918592679106676 [Remote electronic resource, Videorecording]