Vitamin B 12 - MeSH

Select item 680148051.

A cobalt-containing coordination compound produced by intestinal micro-organisms and found also in soil and water. Higher plants do not concentrate vitamin B 12 from the soil and so are a poor source of the substance as compared with animal tissues. INTRINSIC FACTOR is important for the assimilation of vitamin B 12.

Select item 680148062.

Vitamin B 12 Deficiency

A nutritional condition produced by a deficiency of VITAMIN B 12 in the diet, characterized by megaloblastic anemia. Since vitamin B 12 is not present in plants, humans have obtained their supply from animal products, from multivitamin supplements in the form of pills, and as additives to food preparations. A wide variety of neuropsychiatric abnormalities is also seen in vitamin B 12 deficiency and appears to be due to an undefined defect involving myelin synthesis. (From Cecil Textbook of Medicine, 19th ed, p848)

Select item 680141553.

Transcobalamins

A group of carrier proteins which bind with VITAMIN B12 in the BLOOD and aid in its transport. Transcobalamin I migrates electrophoretically as a beta-globulin, while transcobalamins II and III migrate as alpha-globulins.

Year introduced: 1984(1975)

Select item 670464414.

cyanocobalamin, pyridoxine, thiamine drug combination [Supplementary Concept]

consists of above 3 cpds

Date introduced: October 8, 1985

Select item 680030385.

Cobamides

Year introduced: 1974(1972)

Select item 670518356.

2-methylsulfonyladenylcobamide [Supplementary Concept]

from sewage sludge; structure given in first source

Date introduced: April 17, 1987