Down-Regulation

A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

Year introduced: 2002 (1990)

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Tree Number(s): G02.111.240, G05.308.200, G07.690.773.937

MeSH Unique ID: D015536

Entry Terms:

• Down Regulation
• Down-Regulation (Physiology)
• Downregulation
• Receptor Down-Regulation
• Down-Regulation, Receptor

See Also:

• Up-Regulation
• Feedback, Physiological

All MeSH Categories
Phenomena and Processes Category
Chemical Phenomena
Biochemical Phenomena
Down-Regulation

All MeSH Categories
Phenomena and Processes Category
Genetic Phenomena
Gene Expression Regulation
Down-Regulation

All MeSH Categories
Phenomena and Processes Category
Physiological Phenomena
Pharmacological and Toxicological Phenomena
Pharmacological Phenomena
Down-Regulation