MeSH

The material of CHROMOSOMES. It is a complex of DNA; HISTONES; and nonhistone proteins (CHROMOSOMAL PROTEINS, NON-HISTONE) found within the nucleus of a cell.

Year introduced: 1972

A histone chaperone protein that plays a role in the deposition of NUCLEOSOMES on newly synthesized DNA. It is comprised of three different subunits of 48, 60, and 150 kDa molecular size. The 48 kDa subunit, RETINOBLASTOMA-BINDING PROTEIN 4, is also a component of several other protein complexes involved in chromatin remodeling.

Year introduced: 2010(1995)

A technique for identifying specific DNA sequences that are bound, in vivo, to proteins of interest. It involves formaldehyde fixation of CHROMATIN to crosslink the DNA-BINDING PROTEINS to the DNA. After shearing the DNA into small fragments, specific DNA-protein complexes are isolated by immunoprecipitation with protein-specific ANTIBODIES. Then, the DNA isolated from the complex can be identified by PCR amplification and sequencing.

Year introduced: 2005

The mechanisms effecting establishment, maintenance, and modification of that specific physical conformation of CHROMATIN determining the transcriptional accessibility or inaccessibility of the DNA.

Year introduced: 2004

In the interphase nucleus, a condensed mass of chromatin representing an inactivated X chromosome. Each X CHROMOSOME, in excess of one, forms sex chromatin (Barr body) in the mammalian nucleus. (from King and Stansfield, A Dictionary of Genetics, 4th ed)

A technique for identifying the BINDING SITES on nucleic acid sequences that are associated with binding proteins.

Year introduced: 2020

A retinoblastoma-binding protein that is involved in CHROMATIN REMODELING, histone deacetylation, and repression of GENETIC TRANSCRIPTION. Although initially discovered as a retinoblastoma binding protein it has an affinity for core HISTONES and is a subunit of chromatin assembly factor-1 and polycomb repressive complex 2.

Year introduced: 2010

Short chains of RNA (100-300 nucleotides long) that are abundant in the nucleus and usually complexed with proteins in snRNPs (RIBONUCLEOPROTEINS, SMALL NUCLEAR). Many function in the processing of messenger RNA precursors. Others, the snoRNAs (RNA, SMALL NUCLEOLAR), are involved with the processing of ribosomal RNA precursors.

Year introduced: 1986

Date introduced: August 13, 2009

RefSeq NM_079630

Date introduced: February 13, 1998

RefSeq NM_028083

Date introduced: August 13, 2009

RefSeq NM_013733

Date introduced: August 13, 2009

a chloroplast splicing factor; RefSeq NM_127560

Date introduced: March 17, 2007

RefSeq NM_181603

Date introduced: January 21, 2007

RefSeq NM_014977

Date introduced: October 19, 1999

hydrolyzes the 3'-phosphate end of a polynucleotide duplex followed by ATP-mediated phosphorylation of the 5'-OH end

Date introduced: December 3, 1986

conjugate of histone 2A & ubiquitin

Date introduced: January 1, 1980

RefSeq NM_005483

Date introduced: July 17, 2018

A component of the SWI-SNF CHROMATIN REMODELING complex that functions as a PROTEIN PHOSPHATASE 1 regulator and to stabilize CHROMATIN at PROMOTER REGIONS. It is important for regulating CELL PROLIFERATION and CELL DIFFERENTIATION. Mutations in the SMARCB1 gene are associated with malignant RHABDOID TUMORS.

Year introduced: 2017

A family of low-molecular weight, non-histone proteins found in chromatin.

Year introduced: 1985