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Caffeine
A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling.
acetaminophen, butalbital, caffeine drug combination [Supplementary Concept]
drug combination consisting of acetaminophen, butalbital, & caffeine
Date introduced: July 1, 1988
caffeine, sodium benzoate drug combination [Supplementary Concept]
RN given refers to an equal mixture of caffeine and benzoate; Merck, 9th ed, #1628 reference for caffeine sodium benzoate
Date introduced: October 21, 1980
aspirin, butalbital and caffeine drug combination [Supplementary Concept]
combination drug of butalbital, caffeine and aspirin
Date introduced: January 1, 1972
Cytochrome P-450 CYP1A2
A cytochrome P450 enzyme subtype that has specificity for relatively planar heteroaromatic small molecules, such as CAFFEINE and ACETAMINOPHEN.
Year introduced: 1997
caffeine, chlorcyclizine, codeine, ergotamine drug combination [Supplementary Concept]
Date introduced: June 25, 2010
acetaminophen, aspirin, caffeine drug combination [Supplementary Concept]
Date introduced: March 14, 1998
caffeine, codeine, acetaminophen, propyphenazone drug combination [Supplementary Concept]
Date introduced: July 2, 1997
caffeine, chlorpheniramine, dihydrocodeine, methylephedrine drug combination [Supplementary Concept]
Date introduced: March 15, 1990
acetaminophen, caffeine, guaifenesin drug combination [Supplementary Concept]
combination of above 3 cpds
Date introduced: August 26, 1986
caffeine, ergotamine drug combination [Supplementary Concept]
combination of caffeine & ergotamine tartrate
Date introduced: March 22, 1983
caffeine, ephedrine drug combination [Supplementary Concept]
contains above two cpds
Date introduced: June 23, 1981
bucetin, caffeine, dibenzoylthiamine, ethenzamide drug combination [Supplementary Concept]
Date introduced: April 17, 1980
aspirin, caffeine, phenacetin drug combination [Supplementary Concept]
headache powder (Australia)
Date introduced: January 1, 1979
ascorbic acid, B2, B6, bendazol, caffeine, citric acid, distilled H2O, ethanol, gelatin, glutamic acid, KCl, MgCl2, NaCl, sorbitol, sucrose, vitamins B1 drug combination [Supplementary Concept]
Russian drug; contains sucrose 50g, nutritive sorbitol 50g, redistilled ethanol 50g, caffeine 0.1g, bendazol 0.05g, citric acid 2g, KCl 0.42g, NaCl 8.5g, MgCl2 0.025g, ascorbic acid 0.6g, glutamic acid 0.1g, vitamins B1, B2, B6 0.004g, solution of partially hydrolyzed nutritive gelatin (8%, 200ml), & distilled H2O to one liter
Date introduced: January 1, 1978
caffeine, camylofin, ergotamine, mecloxamine, propyphenazone drug combination [Supplementary Concept]
Date introduced: January 1, 1973
caffeine:ubiquinone oxidoreductase, Pseudomonas [Supplementary Concept]
catalyzes the conversion of caffeine, ubiquinone, and water to trimethylurate and ubiquinol; used for rapid testing for caffeine in mother's milk, beverages, and pharmaceuticals
Date introduced: March 10, 2015
CID-1 proterin, C elegans [Supplementary Concept]
checkpoint protein essential for normal development and adult somatic maintenance; has been sequenced
Date introduced: June 19, 2006
CID-1 proterin, S pombe [Supplementary Concept]
caffeine oxidase [Supplementary Concept]
catalyzes oxidation of caffeine at the C-8 position to 1,3,7-trimethyluric acid
Date introduced: November 5, 1999