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Nogalamycin
An anthrocycline from a Streptomyces nogalater variant. It is a cytolytic antineoplastic that inhibits DNA-dependent RNA synthesis by binding to DNA.
Year introduced: 1991(1976)
nogalonic acid methyl ester cyclase [Supplementary Concept]
isolated from Streptomyces nogalater; catalyzes the last ring-closure step in the biosynthesis of the polyketide antibiotic nogalamycin; amino acid sequence in first source; GenBank AF18532
Date introduced: March 21, 2000
viriplanin A [Supplementary Concept]
an anthracycline antibiotic of the nogalamycin group; isolated from Ampullariella regularis; shows activity against Herpes simplex viruses; contains several sugar moieties
Date introduced: December 22, 1986