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Nerve Growth Factor
NERVE GROWTH FACTOR is the first of a series of neurotrophic factors that were found to influence the growth and differentiation of sympathetic and sensory neurons. It is comprised of alpha, beta, and gamma subunits. The beta subunit is responsible for its growth stimulating activity.
Year introduced: 2000
Receptor, Nerve Growth Factor
A low affinity receptor that binds NERVE GROWTH FACTOR; BRAIN-DERIVED NEUROTROPHIC FACTOR; NEUROTROPHIN 3; and neurotrophin 4.
Year introduced: 2000(1994)
Receptors, Nerve Growth Factor
Cell surface receptors that bind NERVE GROWTH FACTOR; (NGF) and a NGF-related family of neurotrophic factors that includes neurotrophins, BRAIN-DERIVED NEUROTROPHIC FACTOR and CILIARY NEUROTROPHIC FACTOR.
Year introduced: 1993
Nuclear Receptor Subfamily 4, Group A, Member 1
An orphan nuclear receptor that is closely related to members of the thyroid-steroid receptor gene family. It was originally identified in NERVE CELLS and may play a role in mediation of NERVE GROWTH FACTOR-induced CELL DIFFERENTIATION. However, several other functions have been attributed to this protein including the positive and negative regulation of APOPTOSIS.
Year introduced: 2010(1991)
Neural Cell Adhesion Molecule L1
A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.
Year introduced: 2003
Neurotrophin 3
A neurotrophic factor involved in regulating the survival of visceral and proprioceptive sensory neurons. It is closely homologous to nerve growth factor beta and BRAIN-DERIVED NEUROTROPHIC FACTOR.
NGF protein, human [Supplementary Concept]
RefSeq NM_002506
Date introduced: July 21, 2005
NGFR protein, human [Supplementary Concept]
RefSeq NM_002507
Date introduced: November 2, 2004
2.5S nerve growth factor [Supplementary Concept]
can induce neurite outgrowth of ganglia; has different biological activity than the 7S nerve growth factor in vitro
Date introduced: July 14, 1993
Ngfr protein, rat [Supplementary Concept]
a high affinity binding protein for the regulatory subunit of cAMP-dependent protein kinase IIbeta; RefSeq NM_012610
Date introduced: May 14, 1991
Glial Cell Line-Derived Neurotrophic Factor
The founding member of the glial cell line-derived neurotrophic factor family. It was originally characterized as a NERVE GROWTH FACTOR promoting the survival of MIDBRAIN dopaminergic NEURONS, and it has been studied as a potential treatment for PARKINSON DISEASE.
Year introduced: 2006(1993)
Receptor, trkA
A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN 3; neurotrophin 4, neurotrophin 5. It plays a crucial role in pain sensation and thermoregulation in humans. Gene mutations that cause loss of receptor function are associated with CONGENITAL INSENSITIVITY TO PAIN WITH ANHIDROSIS, while gene rearrangements that activate the protein-tyrosine kinase function are associated with tumorigenesis.
Brain-Derived Neurotrophic Factor
A member of the nerve growth factor family of trophic factors. In the brain BDNF has a trophic action on retinal, cholinergic, and dopaminergic neurons, and in the peripheral nervous system it acts on both motor and sensory neurons. (From Kendrew, The Encyclopedia of Molecular Biology, 1994)
Year introduced: 1997
PC12 Cells
A CELL LINE derived from a PHEOCHROMOCYTOMA of the rat ADRENAL MEDULLA. PC12 cells stop dividing and undergo terminal differentiation when treated with NERVE GROWTH FACTOR, making the line a useful model system for NERVE CELL differentiation.
Year introduced: 1992
cystacyclin [Supplementary Concept]
a nerve growth factor mimetic isolated from Streptomyces endus; structure in first source
Date introduced: February 20, 2014
juniperigiside [Supplementary Concept]
from the trunk of Abies holophylla; showed significant induction of nerve growth factor secretion; structure in first source
Date introduced: February 4, 2014
ligraminol E 4-O-beta-D-xyloside [Supplementary Concept]
(8R,9S,7'S,8'R)-4,4',7'-trihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan [Supplementary Concept]
bis(N-succinyl-glutamyllysin)hexamethylenediamine [Supplementary Concept]
a nerve growth factor with neuroprotective activity
Date introduced: June 24, 2012
N-docosahexaenoylethanolamide [Supplementary Concept]
a nerve growth factor; structure in first source
Date introduced: September 15, 2011