"Nerve Growth Factor" - MeSH

Search results

Items: 1 to 20 of 79

<< First< Prev

Page of 4

Select item 680209321.

NERVE GROWTH FACTOR is the first of a series of neurotrophic factors that were found to influence the growth and differentiation of sympathetic and sensory neurons. It is comprised of alpha, beta, and gamma subunits. The beta subunit is responsible for its growth stimulating activity.

Year introduced: 2000

Select item 680208002.

Receptor, Nerve Growth Factor

A low affinity receptor that binds NERVE GROWTH FACTOR; BRAIN-DERIVED NEUROTROPHIC FACTOR; NEUROTROPHIN 3; and neurotrophin 4.

Year introduced: 2000(1994)

Select item 680174753.

Receptors, Nerve Growth Factor

Cell surface receptors that bind NERVE GROWTH FACTOR; (NGF) and a NGF-related family of neurotrophic factors that includes neurotrophins, BRAIN-DERIVED NEUROTROPHIC FACTOR and CILIARY NEUROTROPHIC FACTOR.

Year introduced: 1993

Select item 680571054.

Nuclear Receptor Subfamily 4, Group A, Member 1

An orphan nuclear receptor that is closely related to members of the thyroid-steroid receptor gene family. It was originally identified in NERVE CELLS and may play a role in mediation of NERVE GROWTH FACTOR-induced CELL DIFFERENTIATION. However, several other functions have been attributed to this protein including the positive and negative regulation of APOPTOSIS.

Year introduced: 2010(1991)

Select item 680398425.

Neural Cell Adhesion Molecule L1

A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.

Year introduced: 2003

Select item 680209336.

Neurotrophin 3

A neurotrophic factor involved in regulating the survival of visceral and proprioceptive sensory neurons. It is closely homologous to nerve growth factor beta and BRAIN-DERIVED NEUROTROPHIC FACTOR.

Year introduced: 2000

Select item 675022407.

NGF protein, human [Supplementary Concept]

RefSeq NM_002506

Date introduced: July 21, 2005

Select item 674840658.

NGFR protein, human [Supplementary Concept]

RefSeq NM_002507

Date introduced: November 2, 2004

Select item 670817229.

2.5S nerve growth factor [Supplementary Concept]

can induce neurite outgrowth of ganglia; has different biological activity than the 7S nerve growth factor in vitro

Date introduced: July 14, 1993

Select item 6706831310.

Ngfr protein, rat [Supplementary Concept]

a high affinity binding protein for the regulatory subunit of cAMP-dependent protein kinase IIbeta; RefSeq NM_012610

Date introduced: May 14, 1991

Select item 6805110011.

Glial Cell Line-Derived Neurotrophic Factor

The founding member of the glial cell line-derived neurotrophic factor family. It was originally characterized as a NERVE GROWTH FACTOR promoting the survival of MIDBRAIN dopaminergic NEURONS, and it has been studied as a potential treatment for PARKINSON DISEASE.

Year introduced: 2006(1993)

Select item 6802091712.

Receptor, trkA

A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN 3; neurotrophin 4, neurotrophin 5. It plays a crucial role in pain sensation and thermoregulation in humans. Gene mutations that cause loss of receptor function are associated with CONGENITAL INSENSITIVITY TO PAIN WITH ANHIDROSIS, while gene rearrangements that activate the protein-tyrosine kinase function are associated with tumorigenesis.

Year introduced: 2000

Select item 6801920813.

Brain-Derived Neurotrophic Factor

A member of the nerve growth factor family of trophic factors. In the brain BDNF has a trophic action on retinal, cholinergic, and dopaminergic neurons, and in the peripheral nervous system it acts on both motor and sensory neurons. (From Kendrew, The Encyclopedia of Molecular Biology, 1994)

Year introduced: 1997

Select item 6801671614.

PC12 Cells

A CELL LINE derived from a PHEOCHROMOCYTOMA of the rat ADRENAL MEDULLA. PC12 cells stop dividing and undergo terminal differentiation when treated with NERVE GROWTH FACTOR, making the line a useful model system for NERVE CELL differentiation.

Year introduced: 1992

Select item 6758648715.

cystacyclin [Supplementary Concept]

a nerve growth factor mimetic isolated from Streptomyces endus; structure in first source

Date introduced: February 20, 2014

Select item 6758613716.

juniperigiside [Supplementary Concept]

from the trunk of Abies holophylla; showed significant induction of nerve growth factor secretion; structure in first source

Date introduced: February 4, 2014

Select item 6758613617.

ligraminol E 4-O-beta-D-xyloside [Supplementary Concept]

from the trunk of Abies holophylla; showed significant induction of nerve growth factor secretion; structure in first source