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Mitomycin
An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
Year introduced: 2000(1992)
2,3-(distearoyloxy)propane-1-dithio-4'-benzyloxycarbonyl-mitomycin C [Supplementary Concept]
a mitomycin C prodrug; structure in first source
Date introduced: November 18, 2006
mitomycin A [Supplementary Concept]
RN given refers to (1aS-(1aalpha,8beta,8aalpha,8balpha))-isomer; structure given in first source
Date introduced: August 13, 1985
Porfiromycin
Toxic antibiotic of the mitomycin group, obtained from MITOMYCIN and also from Streptomyces ardus and other species. It is proposed as an antineoplastic agent, with some antibiotic properties.
Year introduced: 1991(1982)1973
Woods Leversha Rogers syndrome [Supplementary Concept]
Date introduced: August 25, 2010
mitomycin D [Supplementary Concept]
RN given for (1aS-(1aalpha,8alpha,8aalpha,8balpha))-isomer; structure in first source
Date introduced: December 6, 1996
mcrB protein, Streptomyces lavendulae [Supplementary Concept]
the mcr locus contains 2 genes (mcrA and mcrB) that together confer resistance to mitomycin C; mcrB is a putative transcriptional activator; amino acid sequence in first source; do not confuse with McrB endonuclease
Date introduced: August 1, 1994
mcrA protein, Streptomyces lavendulae [Supplementary Concept]
Mitomycin radical oxidase; confers resistance to mitomycin C; oxidizes reduced form of mitomycins; isolated from Streptomyces lavendulae; amino acid sequence in first source; do not confuse with McrA endonuclease; GenBank L29247
KW 2149 [Supplementary Concept]
derivative of mitomycin C; structure in first source
Date introduced: December 8, 1988
mitomycin C-DNA adduct [Supplementary Concept]
complex of mitomycin C and DNA from Micrococcus luteus; structure given in first source
Date introduced: August 3, 1988
N-7-(2-(nitrophenyldithio)ethyl)mitomycin C [Supplementary Concept]
better antitumor activity than mitomycin C
Date introduced: April 13, 1988
N(6)-((dimethylamino)methylene)mitomycin C [Supplementary Concept]
mitomycin C analog; structure given in first source
Date introduced: November 27, 1985
mitomycin C-dextran [Supplementary Concept]
polymeric prodrug of mitomycin C-dextran conjugate; structure given in first source
Date introduced: November 1, 1984
1 alpha-(4-(N-succinimidoxycarbonyl)butyryl)mitomycin C [Supplementary Concept]
intermediate in mitomycin C conjugate with alpha-fetoprotein antibody; structure given in first source
Date introduced: October 30, 1984
7-N-(4-hydroxyphenyl)mitomycin C [Supplementary Concept]
Date introduced: December 18, 1980
Zinostatin
An enediyne that alkylates DNA and RNA like MITOMYCIN does, so it is cytotoxic.
Year introduced: 1993
Mitomycins
A group of methylazirinopyrroloindolediones obtained from certain Streptomyces strains. They are very toxic antibiotics used as ANTINEOPLASTIC AGENTS in some solid tumors. PORFIROMYCIN and MITOMYCIN are the most useful members of the group.
Year introduced: 1982
Lymphocyte Culture Test, Mixed
Measure of histocompatibility at the HL-A locus. Peripheral blood lymphocytes from two individuals are mixed together in tissue culture for several days. Lymphocytes from incompatible individuals will stimulate each other to proliferate significantly (measured by tritiated thymidine uptake) whereas those from compatible individuals will not. In the one-way MLC test, the lymphocytes from one of the individuals are inactivated (usually by treatment with MITOMYCIN or radiation) thereby allowing only the untreated remaining population of cells to proliferate in response to foreign histocompatibility antigens.
Carbazilquinone
An alkylating agent structurally similar to MITOMYCIN and found to be effective in the treatment of leukemia and various other neoplasms in mice. It causes leukemia and thrombocytopenia in almost all human patients.
Year introduced: 1991(1975)
GMI1 protein, Arabidopsis [Supplementary Concept]
Date introduced: November 12, 2013