Duocarmycins

A group of pyrroloindole compounds often with additional spirocyclic unit(s) and their analogs originally isolated from STREPTOMYCES. They bind DNA minor grooves with adenine-N3 alkylation activity.

Year introduced: 2020

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Tree Number(s): D03.383.129.578.275, D03.633.100.473.278

MeSH Unique ID: D000080890

Entry Terms:

• Duocarmycin

Previous Indexing:

• Indoles (1988-2019)
• Pyrroles (1988-2019)

Pharmacologic Action:

• Antibiotics, Antineoplastic
• Antineoplastic Agents, Alkylating

All MeSH Categories
Chemicals and Drugs Category
Heterocyclic Compounds
Heterocyclic Compounds, 1-Ring
Azoles
Pyrroles
Duocarmycins

All MeSH Categories
Chemicals and Drugs Category
Heterocyclic Compounds
Heterocyclic Compounds, Fused-Ring
Heterocyclic Compounds, 2-Ring
Indoles
Duocarmycins