Granulomatous Disease, Chronic
A defect of leukocyte function in which phagocytic cells ingest but fail to digest bacteria, resulting in recurring bacterial infections with granuloma formation. When chronic granulomatous disease is caused by mutations in the CYBB gene, the condition is inherited in an X-linked recessive pattern. When chronic granulomatous disease is caused by CYBA, NCF1, NCF2, or NCF4 gene mutations, the condition is inherited in an autosomal recessive pattern.
Year introduced: 1978(1975)
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Subheadings:
Tree Number(s): C15.378.553.774.535, C16.320.322.233, C20.673.774.535, C23.550.291.500.423
MeSH Unique ID: D006105
Entry Terms:
- Chronic Granulomatous Diseases
- Granulomatous Diseases, Chronic
- Chronic Granulomatous Disease
- Granulomatous Disease, Chronic, X-Linked
- Chronic Granulomatous Disease, X-Linked
- Chronic Granulomatous Disease, X Linked
- Cytochrome B-Negative Granulomatous Disease, Chronic, X-Linked
- Cytochrome B-Positive Granulomatous Disease, Chronic, X-Linked
- Granulomatous Disease, Chronic, X-Linked, Variant
- Chronic Granulomatous Disease, Atypical
- X-Linked Chronic Granulomatous Disease
- X Linked Chronic Granulomatous Disease
- Autosomal Recessive Chronic Granulomatous Disease
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