Pentostatin

A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.

Year introduced: 1997 (1990)

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Tree Number(s): D03.383.742.680.350.200.700, D13.570.230.677, D13.570.685.350.200.700

MeSH Unique ID: D015649

Registry Number: 395575MZO7

Entry Terms:

• NSC-218321
• NSC218321
• NSC 218321
• CI-825
• CI825
• CI 825
• Nipent
• Co-Vidarabine
• Deoxycoformycin
• Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (R)-
• 2'-Deoxycoformycin
• 2' Deoxycoformycin

Previous Indexing:

• Azepines (1966-1978)
• Coformycin/analogs and derivatives (1979-1989)
• Deoxyribonucleosides (1971-1978)

Pharmacologic Action:

• Antineoplastic Agents
• Adenosine Deaminase Inhibitors

All MeSH Categories
Chemicals and Drugs Category
Heterocyclic Compounds
Heterocyclic Compounds, 1-Ring
Pyrimidines
Pyrimidine Nucleosides
Formycins
Coformycin
Pentostatin

All MeSH Categories
Chemicals and Drugs Category
Nucleic Acids, Nucleotides, and Nucleosides
Nucleosides
Deoxyribonucleosides
Pentostatin

All MeSH Categories
Chemicals and Drugs Category
Nucleic Acids, Nucleotides, and Nucleosides
Nucleosides
Pyrimidine Nucleosides
Formycins
Coformycin
Pentostatin